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Open Access
Peer-reviewed
Research Article
Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model
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Zineb Belcaid,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Jillian A. Phallen,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Jing Zeng,
Affiliation Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Alfred P. See,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Dimitrios Mathios,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Chelsea Gottschalk,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Sarah Nicholas,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Meghan Kellett,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Jacob Ruzevick,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Christopher Jackson,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Emilia Albesiano,
Affiliation Department of Oncology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Nicholas M. Durham,
Affiliation Department of Oncology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Xiaobu Ye,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Phuoc T. Tran,
Affiliation Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Betty Tyler,
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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John W. Wong,
Affiliation Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Henry Brem,
Affiliations Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Departments of Oncology, Ophthalmology, and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Drew M. Pardoll,
Affiliation Department of Oncology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Charles G. Drake,
Affiliation Department of Oncology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Michael Lim
* E-mail: mlim3@jhmi.edu
Affiliation Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model
- Zineb Belcaid,
- Jillian A. Phallen,
- Jing Zeng,
- Alfred P. See,
- Dimitrios Mathios,
- Chelsea Gottschalk,
- Sarah Nicholas,
- Meghan Kellett,
- Jacob Ruzevick,
- Christopher Jackson

- Published: July 11, 2014
- https://doi.org/10.1371/journal.pone.0101764