Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function

• Wenbo Tang ,

  ¶These authors are joint first authors on this work.

  Affiliation Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America

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• Matthew Kowgier ,

  ¶These authors are joint first authors on this work.

  Affiliation Ontario Institute for Cancer Research and Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

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• Daan W. Loth ,

  ¶These authors are joint first authors on this work.

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, Netherlands Healthcare Inspectorate, The Hague, the Netherlands

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• María Soler Artigas ,

  ¶These authors are joint first authors on this work.

  Affiliations University of Leicester, Genetic Epidemiology Group, Department of Health Sciences, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom

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• Bonnie R. Joubert ,

  ¶These authors are joint first authors on this work.

  Affiliation Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

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• Emily Hodge ,

  ¶These authors are joint first authors on this work.

  Affiliation Division of Respiratory Medicine, University Hospital of Nottingham, Nottingham, United Kingdom

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• Sina A. Gharib ,

  ¶These authors are joint first authors on this work.

  Affiliation Computational Medicine Core, Center for Lung Biology, Division of Pulmonary & Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Albert V. Smith,

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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• Ingo Ruczinski,

  Affiliation Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Vilmundur Gudnason,

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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• Rasika A. Mathias,

  Affiliation Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Tamara B. Harris,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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• Nadia N. Hansel,

  Affiliation Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Lenore J. Launer,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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• Kathleen C. Barnes,

  Affiliation Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Joyanna G. Hansen,

  Affiliation Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America

  ⨯
• Eva Albrecht,

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany

  ⨯
• Melinda C. Aldrich,

  Affiliation Department of Thoracic Surgery and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

  ⨯
• Michael Allerhand,

  Affiliation Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom

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• R. Graham Barr,

  Affiliations Division of General Medicine, Pulmonary, Allergy and Critical Care, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America

  ⨯
• Guy G. Brusselle,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium, Department of Respiratory Medicine, Erasmus Medical Center, Rotterdam, the Netherlands, 22 Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• David J. Couper,
• Ivan Curjuric,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

  ⨯
• Gail Davies,

  Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, Medical Genetics Section, University of Edinburgh Molecular Medicine Centre and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Ian J. Deary,

  Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Josée Dupuis,

  Affiliations Biostatistics Department, Boston University School of Public Health, Boston, Massachusetts, United States of America, The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

  ⨯
• Tove Fall,

  Affiliation Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

  ⨯
• Millennia Foy,

  Affiliation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Nora Franceschini,

  Affiliation Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• Wei Gao,

  Affiliation Biostatistics Department, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Sven Gläser,

  Affiliation Department of Internal Medicine B; Pneumology, Cardiology, Intensive Care Medicine; Field of Research: Pneumology and Pneumological Epidemiology, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Xiangjun Gu,

  Affiliation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Dana B. Hancock,

  Affiliations Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America, Behavioral Health Epidemiology Program, Research Triangle Institute, Research Triangle Park, North Carolina, United States of America

  ⨯
• Joachim Heinrich,

  Affiliation Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany and Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany

  ⨯
• Albert Hofman,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, Netherlands Consortium for Healthy Aging, Rotterdam, the Netherlands

  ⨯
• Medea Imboden,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

  ⨯
• Erik Ingelsson,

  Affiliations Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK and Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

  ⨯
• Alan James,

  Affiliation School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia

  ⨯
• Stefan Karrasch,

  Affiliations Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany, Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany, Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany

  ⨯
• Beate Koch,

  Affiliation Department of Internal Medicine B; Pneumology, Cardiology, Intensive Care Medicine; Field of Research: Pneumology and Pneumological Epidemiology, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Stephen B. Kritchevsky,

  Affiliation Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Ashish Kumar,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK and Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

  ⨯
• Lies Lahousse,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium

  ⨯
• Guo Li,

  Affiliation Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America

  ⨯
• Lars Lind,

  Affiliation Department of Medical Sciences, Uppsala University, Uppsala, Sweden

  ⨯
• Cecilia Lindgren,

  Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK and Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  ⨯
• Yongmei Liu,

  Affiliation Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Kurt Lohman,

  Affiliation Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Thomas Lumley,

  Affiliation Department of Statistics, University of Auckland, Auckland, New Zealand

  ⨯
• Wendy L. McArdle,

  Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

  ⨯
• Bernd Meibohm,

  Affiliation College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  ⨯
• Andrew P. Morris,

  Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK and Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

  ⨯
• Alanna C. Morrison,

  Affiliation Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Bill Musk,

  Affiliation School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia

  ⨯
• Kari E. North,

  Affiliation Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• Lyle J. Palmer,

  Affiliations Ontario Institute for Cancer Research and Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada, Epidemiology and Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada

  ⨯
• Nicole M. Probst-Hensch,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

  ⨯
• Bruce M. Psaty,

  Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Fernando Rivadeneira,

  Affiliations Netherlands Consortium for Healthy Aging, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

  ⨯
• Jerome I. Rotter,

  Affiliation Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of America

  ⨯
• Holger Schulz,

  Affiliation Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany and Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany

  ⨯
• Lewis J. Smith,

  Affiliation Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  ⨯
• Akshay Sood,

  Affiliation University of New Mexico, Albuquerque, New Mexico, United States of America

  ⨯
• John M. Starr,

  Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• David P. Strachan,

  Affiliation Division of Population Health Sciences and Education, St George's, University of London, London, United Kingdom

  ⨯
• Alexander Teumer,

  Affiliation Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

  ⨯
• André G. Uitterlinden,

  Affiliations Netherlands Consortium for Healthy Aging, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

  ⨯
• Henry Völzke,

  Affiliation Institute for Community Medicine, Study of Health In Pomerania (SHIP)/Clinical Epidemiological Research, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Arend Voorman,

  Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

  ⨯
• Louise V. Wain,

  Affiliations University of Leicester, Genetic Epidemiology Group, Department of Health Sciences, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom

  ⨯
• Martin T. Wells,

  Affiliation Department of Statistical Science, Cornell University, Ithaca, New York, United States of America

  ⨯
• Jemma B. Wilk,

  Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• O. Dale Williams,

  Affiliation Florida International University, Miami, Florida, United States of America

  ⨯
• Susan R. Heckbert,

  Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

  ⨯
• Bruno H. Stricker,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, Netherlands Healthcare Inspectorate, The Hague, the Netherlands

  ⨯
• Stephanie J. London,

  Affiliation Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

  ⨯
• Myriam Fornage ,

  ¶‡ These authors are joint last authors on this work.

  Affiliations Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Martin D. Tobin ,

  ¶‡ These authors are joint last authors on this work.

  Affiliations University of Leicester, Genetic Epidemiology Group, Department of Health Sciences, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom

  ⨯
• George T. O′Connor ,

  ¶‡ These authors are joint last authors on this work.

  Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, Section of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Ian P. Hall ,

  ¶‡ These authors are joint last authors on this work.

  Affiliation Division of Respiratory Medicine, University Hospital of Nottingham, Nottingham, United Kingdom

  ⨯
•  [ ... ],
• Patricia A. Cassano

  * E-mail: pac6@cornell.edu

  ¶‡ These authors are joint last authors on this work.

  Affiliations Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America, Department of Health Care Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York, United States of America

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