Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3β Signaling Pathway

Yuan Hong; AnWen Shao; Jianfeng Wang; Sheng Chen; HaiJian Wu; Devin W. McBride; Qun Wu; XueJun Sun; JianMin Zhang

doi:10.1371/journal.pone.0096212

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Peer-reviewed

Research Article

Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3β Signaling Pathway

Yuan Hong ,

Contributed equally to this work with: Yuan Hong, AnWen Shao

Affiliation Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
⨯
AnWen Shao ,

Contributed equally to this work with: Yuan Hong, AnWen Shao

Affiliation Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
⨯
Jianfeng Wang,

Affiliations Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, Department of Neurosurgery, Taizhou Enze Medical Center (Group), Taizhou Hospital, Taizhou, China
⨯
Sheng Chen,

Affiliation Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
⨯
HaiJian Wu,

Affiliation Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
⨯
Devin W. McBride,

Affiliation Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California, United States of America
⨯
Qun Wu,

Affiliation Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
⨯
XueJun Sun,

Affiliation Department of Diving Medicine, The Second Military Medical University, Shanghai, China
⨯
JianMin Zhang

* E-mail: zjm153vip@sina.com

Affiliation Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
⨯

Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3β Signaling Pathway

Yuan Hong,
AnWen Shao,
Jianfeng Wang,
Sheng Chen,
HaiJian Wu,
Devin W. McBride,
Qun Wu,
XueJun Sun,
JianMin Zhang

Published: April 24, 2014
https://doi.org/10.1371/journal.pone.0096212

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