CD8+ Regulatory T Cells, and Not CD4+ T Cells, Dominate Suppressive Phenotype and Function after In Vitro Live Mycobacterium bovis-BCG Activation of Human Cells

Open Access

Peer-reviewed

Research Article

CD8⁺ Regulatory T Cells, and Not CD4⁺ T Cells, Dominate Suppressive Phenotype and Function after In Vitro Live Mycobacterium bovis-BCG Activation of Human Cells

Mardi C. Boer,

Affiliation Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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Krista E. van Meijgaarden,

Affiliation Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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Simone A. Joosten ,

Contributed equally to this work with: Simone A. Joosten, Tom H. M. Ottenhoff

Affiliation Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
⨯
Tom H. M. Ottenhoff

Contributed equally to this work with: Simone A. Joosten, Tom H. M. Ottenhoff

* E-mail: T.H.M.Ottenhoff@lumc.nl

Affiliation Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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T cells
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Cytotoxic T cells
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Regulatory T cells
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Mycobacterium tuberculosis
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Cloning
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Tuberculosis
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Vaccination and immunization
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Vaccines
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