Micro-Environment Causes Reversible Changes in DNA Methylation and mRNA Expression Profiles in Patient-Derived Glioma Stem Cells

Mehmet Baysan; Kevin Woolard; Serdar Bozdag; Gregory Riddick; Svetlana Kotliarova; Margaret C. Cam; Galina I. Belova; Susie Ahn; Wei Zhang; Hua Song; Jennifer Walling; Holly Stevenson; Paul Meltzer; Howard A. Fine

doi:10.1371/journal.pone.0094045

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Open Access

Peer-reviewed

Research Article

Micro-Environment Causes Reversible Changes in DNA Methylation and mRNA Expression Profiles in Patient-Derived Glioma Stem Cells

Mehmet Baysan,

Affiliation New York University Cancer Institute, New York University Brain Tumor Center, New York University Langone Medical Center, New York, New York, United States of America
⨯
Kevin Woolard,

Affiliation Department of Pathology, Microbiology, and Immunology, University of California Davis, Davis, California, United States of America
⨯
Serdar Bozdag,

Affiliation Department of Mathematics, Statistics, and Computer Science, Marquette University, Milwaukee, Wisconsin, United States of America
⨯
Gregory Riddick,

Affiliation Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Svetlana Kotliarova,

Affiliation Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Margaret C. Cam,

Affiliation Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Galina I. Belova,

Affiliation Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Susie Ahn,

Affiliation Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Wei Zhang,

Affiliation Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Hua Song,

Affiliation Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
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Jennifer Walling,

Affiliation Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Holly Stevenson,

Affiliation Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Paul Meltzer,

Affiliation Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Howard A. Fine

* E-mail: Howard.Fine@nyumc.org

Current address: New York University (NYU) Langone Medical Center, NYU Cancer Institute, New York, New York, United States of America

Affiliation New York University Cancer Institute, New York University Brain Tumor Center, New York University Langone Medical Center, New York, New York, United States of America
⨯

Micro-Environment Causes Reversible Changes in DNA Methylation and mRNA Expression Profiles in Patient-Derived Glioma Stem Cells

Mehmet Baysan,
Kevin Woolard,
Serdar Bozdag,
Gregory Riddick,
Svetlana Kotliarova,
Margaret C. Cam,
Galina I. Belova,
Susie Ahn,
Wei Zhang,
Hua Song

Published: April 11, 2014
https://doi.org/10.1371/journal.pone.0094045

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DNA methylation
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Methylation
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Cancers and neoplasms
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Gene expression
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Malignant tumors
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