Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth

Jonathan W. Kotula; Jinpeng Sun; Margie Li; Elizabeth D. Pratico; Mark P. Fereshteh; Douglas P. Ahrens; Bruce A. Sullenger; Jeffrey J. Kovacs

doi:10.1371/journal.pone.0093441

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Open Access

Peer-reviewed

Research Article

Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth

Jonathan W. Kotula ,

Contributed equally to this work with: Jonathan W. Kotula, Jinpeng Sun

Affiliation Departments of Surgery and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
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Jinpeng Sun ,

Contributed equally to this work with: Jonathan W. Kotula, Jinpeng Sun

Affiliation Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Margie Li,

Affiliation Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America
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Elizabeth D. Pratico,

Affiliation Departments of Surgery and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Mark P. Fereshteh,

Affiliation Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America
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Douglas P. Ahrens,

Affiliation b3 bio, Inc. Research Triangle Park, North Carolina, United States of America
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Bruce A. Sullenger,

Affiliation Departments of Surgery and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
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Jeffrey J. Kovacs

* E-mail: jeff.kovacs@duke.edu

Affiliations Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America, b3 bio, Inc. Research Triangle Park, North Carolina, United States of America
⨯

Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth

Jonathan W. Kotula,
Jinpeng Sun,
Margie Li,
Elizabeth D. Pratico,
Mark P. Fereshteh,
Douglas P. Ahrens,
Bruce A. Sullenger,
Jeffrey J. Kovacs

Published: April 15, 2014
https://doi.org/10.1371/journal.pone.0093441

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