Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition

• Mutsuko Minata ,

  Contributed equally to this work with: Mutsuko Minata, Chunyu Gu

  * E-mail: Ichiro.Nakano@osumc.edu

  Affiliation Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, United States of America

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• Chunyu Gu ,

  Contributed equally to this work with: Mutsuko Minata, Chunyu Gu

  Affiliations Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, United States of America, Departments of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing, China

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• Kaushal Joshi,

  Affiliation Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, United States of America

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• Mariko Nakano-Okuno,

  Affiliation Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio, United States of America

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• Christopher Hong,

  Affiliation Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, United States of America

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• Chi-Hung Nguyen,

  Affiliation Pharmaco-chemistry, UMR 176 CNRS-Institut Curie, Orsay, France

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• Harley I. Kornblum,

  Affiliation Departments of Psychiatry and Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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• Annie Molla,

  Affiliation Institut Albert Bonniot, Université Joseph Fourier, Grenoble Cedex 9, France

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• Ichiro Nakano

  Affiliations Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, United States of America, James Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, United States of America

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