Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9

Yuanwu Ma; Bin Shen; Xu Zhang; Yingdong Lu; Wei Chen; Jing Ma; Xingxu Huang; Lianfeng Zhang

doi:10.1371/journal.pone.0089413

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Open Access

Peer-reviewed

Research Article

Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9

Yuanwu Ma ,

Contributed equally to this work with: Yuanwu Ma, Bin Shen

Affiliation Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China
⨯
Bin Shen ,

Contributed equally to this work with: Yuanwu Ma, Bin Shen

Affiliation MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, Nanjing Biomedical Research Institute, National Resource Center for Mutant Mice, Nanjing, China
⨯
Xu Zhang,

Affiliation Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China
⨯
Yingdong Lu,

Affiliation Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China
⨯
Wei Chen,

Affiliation Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China
⨯
Jing Ma,

Affiliation Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China
⨯
Xingxu Huang ,

* E-mail: xingxuhuang@mail.nju.edu.cn (XH); zhanglf@cnilas.org (LZ)

Affiliation MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, Nanjing Biomedical Research Institute, National Resource Center for Mutant Mice, Nanjing, China
⨯
Lianfeng Zhang

* E-mail: xingxuhuang@mail.nju.edu.cn (XH); zhanglf@cnilas.org (LZ)

Affiliation Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China
⨯

Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9

Yuanwu Ma,
Bin Shen,
Xu Zhang,
Yingdong Lu,
Wei Chen,
Jing Ma,
Xingxu Huang,
Lianfeng Zhang

Published: March 5, 2014
https://doi.org/10.1371/journal.pone.0089413

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