pTyr421 Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1)

Vijayababu M. Radhakrishnan; Pawel Kojs; Gavin Young; Rajalakshmy Ramalingam; Bhumasamudram Jagadish; Eugene A. Mash; Jesse D. Martinez; Fayez K. Ghishan; Pawel R. Kiela

doi:10.1371/journal.pone.0085796

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Research Article

pTyr⁴²¹ Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1)

Vijayababu M. Radhakrishnan,

Affiliation Department of Pediatrics, Steele Children's Research Center, University of Arizona Health Sciences Center, Tucson, Arizona, United States of America
⨯
Pawel Kojs,

Affiliation Department of Nutritional Sciences, Tucson, Arizona, United States of America
⨯
Gavin Young,

Affiliation Arizona Cancer Center, Tucson, Arizona, United States of America
⨯
Rajalakshmy Ramalingam,

Affiliation Department of Pediatrics, Steele Children's Research Center, University of Arizona Health Sciences Center, Tucson, Arizona, United States of America
⨯
Bhumasamudram Jagadish,

Affiliations Arizona Cancer Center, Tucson, Arizona, United States of America, Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona, United States of America
⨯
Eugene A. Mash,

Affiliations Arizona Cancer Center, Tucson, Arizona, United States of America, Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona, United States of America
⨯
Jesse D. Martinez,

Affiliation Arizona Cancer Center, Tucson, Arizona, United States of America
⨯
Fayez K. Ghishan,

Affiliation Department of Pediatrics, Steele Children's Research Center, University of Arizona Health Sciences Center, Tucson, Arizona, United States of America
⨯
Pawel R. Kiela

* E-mail: pkiela@peds.arizona.edu

Affiliations Department of Pediatrics, Steele Children's Research Center, University of Arizona Health Sciences Center, Tucson, Arizona, United States of America, Department of Immunobiology, University of Arizona Health Sciences Center, Tucson, Arizona, United States of America
⨯

pTyr⁴²¹ Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1)

Vijayababu M. Radhakrishnan,
Pawel Kojs,
Gavin Young,
Rajalakshmy Ramalingam,
Bhumasamudram Jagadish,
Eugene A. Mash,
Jesse D. Martinez,
Fayez K. Ghishan,
Pawel R. Kiela

Published: January 22, 2014
https://doi.org/10.1371/journal.pone.0085796

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