Association between CASP8 –652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study

• Barbara Pardini ,

  * E-mail: barbara.pardini@hugef-torino.org

  Affiliation Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation, Turin, Italy

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• Paolo Verderio,

  Affiliation Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy

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• Sara Pizzamiglio,

  Affiliation Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy

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• Carmela Nici,

  Affiliation Fondazione Istituto Italian Foundation for Cancer Research di Oncologia Molecolare, Milan, Italy

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• Maria Valeria Maiorana,

  Affiliation Fondazione Istituto Italian Foundation for Cancer Research di Oncologia Molecolare, Milan, Italy

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• Alessio Naccarati,

  Affiliations Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Turin, Italy, Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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• Ludmila Vodickova,

  Affiliations Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic, First Medical Faculty, Charles University, Prague, Czech Republic

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• Veronika Vymetalkova,

  Affiliations Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic, First Medical Faculty, Charles University, Prague, Czech Republic

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• Silvia Veneroni,

  Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy

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• Maria Grazia Daidone,

  Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy

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• Fernando Ravagnani,

  Affiliation Immunohematology and Transfusion Medicine Service, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy

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• Tiziana Bianchi,

  Affiliation Associazione Italiana Volontari Sangue Comunale Milano, Milan, Italy

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• Luis Bujanda,

  Affiliation Gastroenterology Department, Hospital Donostia, Networked Biomedical Research Centre for Hepatic and Digestive Diseases, Basque Country University, San Sebastián, Spain

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• Angel Carracedo,

  Affiliation Galician Public Foundation of Genomic Medicine, Centro de Investigación Biomédica en Red de Enfermedades Raras, Genomics Medicine Group, Hospital Clínico, Santiago de Compostela, University of Santiago de Compostela, Galicia, Spain

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• Antoni Castells,

  Affiliation Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Catalonia, Spain

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• Clara Ruiz-Ponte,

  Affiliation Galician Public Foundation of Genomic Medicine, Centro de Investigación Biomédica en Red de Enfermedades Raras, Genomics Medicine Group, Hospital Clínico, Santiago de Compostela, University of Santiago de Compostela, Galicia, Spain

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• Hans Morreau,

  Affiliation Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

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• Kimberley Howarth,

  Affiliation Molecular and Population Genetics Laboratory and National Institute for Health Research Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Angela Jones,

  Affiliation Molecular and Population Genetics Laboratory and National Institute for Health Research Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Sergi Castellví-Bel,

  Affiliation Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Catalonia, Spain

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• Li Li,

  Affiliation Department of Family Medicine and Community Health and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Ian Tomlinson,

  Affiliation Molecular and Population Genetics Laboratory and National Institute for Health Research Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Tom Van Wezel,

  Affiliation Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

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• Pavel Vodicka,

  Affiliations Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic, First Medical Faculty, Charles University, Prague, Czech Republic

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• Paolo Radice,

  Affiliation Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy

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• Paolo Peterlongo,

  Affiliation Fondazione Istituto Italian Foundation for Cancer Research di Oncologia Molecolare, Milan, Italy

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•  [ ... ],
• the EPICOLON Consortium

  ¶Members of the EPICOLON Consortium can be found in the acknowledgments.

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