A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers

Rigmor Thorstensson; Birger Trollfors; Nabil Al-Tawil; Maja Jahnmatz; Jakob Bergström; Margaretha Ljungman; Anna Törner; Lena Wehlin; Annie Van Broekhoven; Fons Bosman; Anne-Sophie Debrie; Nathalie Mielcarek; Camille Locht

doi:10.1371/journal.pone.0083449

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Peer-reviewed

Research Article

A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers

Rigmor Thorstensson ,

* E-mail: Rigmor.thorstensson@smi.se

Affiliation Swedish Institute for Communicable Disease Control, Solna, Sweden
⨯
Birger Trollfors,

Affiliation Swedish Institute for Communicable Disease Control, Solna, Sweden
⨯
Nabil Al-Tawil,

Affiliation Karolinska Trial Alliance, Karolinska University Hospital, Stockholm, Sweden
⨯
Maja Jahnmatz,

Affiliations Swedish Institute for Communicable Disease Control, Solna, Sweden, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Jakob Bergström,

Affiliation Swedish Institute for Communicable Disease Control, Solna, Sweden
⨯
Margaretha Ljungman,

Affiliation Swedish Institute for Communicable Disease Control, Solna, Sweden
⨯
Anna Törner,

Affiliation Swedish Institute for Communicable Disease Control, Solna, Sweden
⨯
Lena Wehlin,

Affiliation Swedish Institute for Communicable Disease Control, Solna, Sweden
⨯
Annie Van Broekhoven,

Affiliation Q-Biologicals, BioIncubator, Zwijnaarde, Belgium
⨯
Fons Bosman,

Affiliation Q-Biologicals, BioIncubator, Zwijnaarde, Belgium
⨯
Anne-Sophie Debrie,

Affiliations Inserm, Lille, France, National Center for Scientific Research, Lille, France, Université Lille-Nord de France, Lille, France, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, France
⨯
Nathalie Mielcarek,

Affiliations Inserm, Lille, France, National Center for Scientific Research, Lille, France, Université Lille-Nord de France, Lille, France, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, France
⨯
Camille Locht

Affiliations Inserm, Lille, France, National Center for Scientific Research, Lille, France, Université Lille-Nord de France, Lille, France, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, France
⨯

A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers

Rigmor Thorstensson,
Birger Trollfors,
Nabil Al-Tawil,
Maja Jahnmatz,
Jakob Bergström,
Margaretha Ljungman,
Anna Törner,
Lena Wehlin,
Annie Van Broekhoven,
Fons Bosman

Published: January 8, 2014
https://doi.org/10.1371/journal.pone.0083449

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