Recombinant AAV-Mediated BEST1 Transfer to the Retinal Pigment Epithelium: Analysis of Serotype-Dependent Retinal Effects

Karina E. Guziewicz; Barbara Zangerl; András M. Komáromy; Simone Iwabe; Vincent A. Chiodo; Sanford L. Boye; William W. Hauswirth; William A. Beltran; Gustavo D. Aguirre

doi:10.1371/journal.pone.0075666

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Peer-reviewed

Research Article

Recombinant AAV-Mediated BEST1 Transfer to the Retinal Pigment Epithelium: Analysis of Serotype-Dependent Retinal Effects

Karina E. Guziewicz ,

Contributed equally to this work with: Karina E. Guziewicz, Barbara Zangerl

* E-mail: karinag@vet.upenn.edu (KEG); gda@vet.upenn.edu (GDA)

Affiliation Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Barbara Zangerl ,

Contributed equally to this work with: Karina E. Guziewicz, Barbara Zangerl

* E-mail: karinag@vet.upenn.edu (KEG); gda@vet.upenn.edu (GDA)

Affiliations Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Centre for Eye Health, University of New South Wales, Kensington, Australia
⨯
András M. Komáromy,

Affiliations Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, United States of America
⨯
Simone Iwabe,

Affiliation Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Vincent A. Chiodo,

Affiliation Department of Ophthalmology, University of Florida, Gainesville, Florida, United States of America
⨯
Sanford L. Boye,

Affiliation Department of Ophthalmology, University of Florida, Gainesville, Florida, United States of America
⨯
William W. Hauswirth,

Affiliation Department of Ophthalmology, University of Florida, Gainesville, Florida, United States of America
⨯
William A. Beltran,

Affiliation Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Gustavo D. Aguirre

Affiliation Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Recombinant AAV-Mediated BEST1 Transfer to the Retinal Pigment Epithelium: Analysis of Serotype-Dependent Retinal Effects

Karina E. Guziewicz,
Barbara Zangerl,
András M. Komáromy,
Simone Iwabe,
Vincent A. Chiodo,
Sanford L. Boye,
William W. Hauswirth,
William A. Beltran,
Gustavo D. Aguirre

Published: October 15, 2013
https://doi.org/10.1371/journal.pone.0075666

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