Ablation of the Id2 Gene Results in Altered Circadian Feeding Behavior, and Sex-Specific Enhancement of Insulin Sensitivity and Elevated Glucose Uptake in Skeletal Muscle and Brown Adipose Tissue

Deepa Mathew; Peng Zhou; Cameron M. Pywell; Daan R. van der Veen; Jinping Shao; Yang Xi; Nicolle A. Bonar; Alyssa D. Hummel; Sarah Chapman; W. Matthew Leevy; Giles E. Duffield

doi:10.1371/journal.pone.0073064

Loading metrics

Open Access

Peer-reviewed

Research Article

Ablation of the Id2 Gene Results in Altered Circadian Feeding Behavior, and Sex-Specific Enhancement of Insulin Sensitivity and Elevated Glucose Uptake in Skeletal Muscle and Brown Adipose Tissue

Deepa Mathew,

Affiliation Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Peng Zhou,

Affiliation Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Cameron M. Pywell,

Affiliation Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Daan R. van der Veen,

Current address: Department of Biochemistry and Physiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom

Affiliation Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Jinping Shao,

Current address: Department of Anatomy, Basic Medical College, Zhengzhou University, Zhengzhou, People’s Republic of China

Affiliation Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Yang Xi,

Affiliation Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Nicolle A. Bonar,

Affiliation Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Alyssa D. Hummel,

Affiliation Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Sarah Chapman,

Affiliation Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
W. Matthew Leevy,

Affiliations Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America, Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Giles E. Duffield

* E-mail: duffield.2@nd.edu

Affiliations Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯

Ablation of the Id2 Gene Results in Altered Circadian Feeding Behavior, and Sex-Specific Enhancement of Insulin Sensitivity and Elevated Glucose Uptake in Skeletal Muscle and Brown Adipose Tissue

Deepa Mathew,
Peng Zhou,
Cameron M. Pywell,
Daan R. van der Veen,
Jinping Shao,
Yang Xi,
Nicolle A. Bonar,
Alyssa D. Hummel,
Sarah Chapman,
W. Matthew Leevy

Published: September 2, 2013
https://doi.org/10.1371/journal.pone.0073064

Reader Comments (3)

Post a new comment on this article

2 Responses

11 Nov 2015
16:29 GMT
Most Recent

Figure 1 bars are entitled as Id2-/- and KO, what is the WT? Posted by Abidostov on 03 Nov 2015 at 16:56 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Skeletal muscles
Is the Subject Area "Skeletal muscles" applicable to this article?

Thanks for your feedback.
Glucose metabolism
Is the Subject Area "Glucose metabolism" applicable to this article?

Thanks for your feedback.
Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
Glucose tolerance
Is the Subject Area "Glucose tolerance" applicable to this article?

Thanks for your feedback.
Biological locomotion
Is the Subject Area "Biological locomotion" applicable to this article?

Thanks for your feedback.
Adipocytes
Is the Subject Area "Adipocytes" applicable to this article?

Thanks for your feedback.
Chronobiology
Is the Subject Area "Chronobiology" applicable to this article?

Thanks for your feedback.