Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load

Olivera Stojadinovic; Julia Minkiewicz; Andrew Sawaya; Jonathan W. Bourne; Peter Torzilli; Juan Pablo de Rivero Vaccari; W. Dalton Dietrich; Robert W. Keane; Marjana Tomic-Canic

doi:10.1371/journal.pone.0069223

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Peer-reviewed

Research Article

Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load

Olivera Stojadinovic,

Affiliation Department of Dermatology & Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller Medical School, Miami, Florida, United States of America
⨯
Julia Minkiewicz,

Affiliation Department of Physiology & Biophysics, University of Miami Miller Medical School, Miami, Florida, United States of America
⨯
Andrew Sawaya,

Affiliation Department of Dermatology & Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller Medical School, Miami, Florida, United States of America
⨯
Jonathan W. Bourne,

Affiliation Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, New York, United States of America
⨯
Peter Torzilli,

Affiliation Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, New York, United States of America
⨯
Juan Pablo de Rivero Vaccari,

Affiliation Departments of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
W. Dalton Dietrich,

Affiliation Departments of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Robert W. Keane,

Affiliation Department of Physiology & Biophysics, University of Miami Miller Medical School, Miami, Florida, United States of America
⨯
Marjana Tomic-Canic

* E-mail: MTCanic@med.miami.edu

Affiliation Department of Dermatology & Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller Medical School, Miami, Florida, United States of America
⨯

Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load

Olivera Stojadinovic,
Julia Minkiewicz,
Andrew Sawaya,
Jonathan W. Bourne,
Peter Torzilli,
Juan Pablo de Rivero Vaccari,
W. Dalton Dietrich,
Robert W. Keane,
Marjana Tomic-Canic

Published: August 14, 2013
https://doi.org/10.1371/journal.pone.0069223

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Inflammasomes
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Collagens
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Skin
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Photodermatology and skin aging
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Inflammation
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Aging
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Ulcers
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