Human Folliculin Delays Cell Cycle Progression through Late S and G2/M-Phases: Effect of Phosphorylation and Tumor Associated Mutations

Laura A. Laviolette; Jonas Wilson; Julia Koller; Christopher Neil; Peter Hulick; Tomas Rejtar; Barry Karger; Bin Tean Teh; Othon Iliopoulos

doi:10.1371/journal.pone.0066775

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Peer-reviewed

Research Article

Human Folliculin Delays Cell Cycle Progression through Late S and G2/M-Phases: Effect of Phosphorylation and Tumor Associated Mutations

Laura A. Laviolette,

Affiliations Center for Cancer Research at The Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, United States of America, Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jonas Wilson,

Affiliations Center for Cancer Research at The Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, United States of America, Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America
⨯
Julia Koller,

Affiliations Center for Cancer Research at The Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, United States of America, Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America
⨯
Christopher Neil,

Affiliations Center for Cancer Research at The Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, United States of America, Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America
⨯
Peter Hulick,

Affiliations Center for Cancer Research at The Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, United States of America, Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America
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Tomas Rejtar,

Affiliation Department of Chemistry and Chemical Biology and the Barnett Institute, Northeastern University, Boston, Massachusetts, United States of America
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Barry Karger,

Affiliation Department of Chemistry and Chemical Biology and the Barnett Institute, Northeastern University, Boston, Massachusetts, United States of America
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Bin Tean Teh,

Affiliations Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan, United States of America, NCCS-VARI Translational Research Laboratory, National Cancer Centre Singapore, Singapore
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Othon Iliopoulos

* E-mail: oiliopoulos@partners.org

Affiliations Center for Cancer Research at The Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, United States of America, Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Human Folliculin Delays Cell Cycle Progression through Late S and G2/M-Phases: Effect of Phosphorylation and Tumor Associated Mutations

Laura A. Laviolette,
Jonas Wilson,
Julia Koller,
Christopher Neil,
Peter Hulick,
Tomas Rejtar,
Barry Karger,
Bin Tean Teh,
Othon Iliopoulos

Published: July 11, 2013
https://doi.org/10.1371/journal.pone.0066775

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Cell cycle and cell division
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Phosphorylation
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Renal cancer
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Tumor suppressor genes
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Cancers and neoplasms
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Thymidines
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Renal cell carcinoma
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Serine
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