Novel 5′ Untranslated Region Directed Blockers of Iron-Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation: Implications for Down Syndrome and Alzheimer's Disease

Sanghamitra Bandyopadhyay; Catherine Cahill; Amelie Balleidier; Conan Huang; Debomoy K. Lahiri; Xudong Huang; Jack T. Rogers

doi:10.1371/journal.pone.0065978

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Peer-reviewed

Research Article

Novel 5′ Untranslated Region Directed Blockers of Iron-Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation: Implications for Down Syndrome and Alzheimer's Disease

Sanghamitra Bandyopadhyay,

Current address: Developmental Toxicology Division, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, India

Affiliation Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Catherine Cahill,

Affiliations Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Amelie Balleidier,

Affiliation Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Conan Huang,

Affiliation Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Debomoy K. Lahiri,

Affiliation Laboratory of Molecular Neurogenetics, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Xudong Huang,

Affiliation Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Jack T. Rogers

* E-mail: jrogers@partners.org

Affiliation Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯

Novel 5′ Untranslated Region Directed Blockers of Iron-Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation: Implications for Down Syndrome and Alzheimer's Disease

Sanghamitra Bandyopadhyay,
Catherine Cahill,
Amelie Balleidier,
Conan Huang,
Debomoy K. Lahiri,
Xudong Huang,
Jack T. Rogers

Published: July 31, 2013
https://doi.org/10.1371/journal.pone.0065978

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Internal ribosome entry site
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Messenger RNA
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Protein translation
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Neurons
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Benzimidazoles
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Iron
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Alzheimer's disease
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Transfection
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