Identification of Subunit-Subunit Interaction Sites in αA-WT Crystallin and Mutant αA-G98R Crystallin Using Isotope-Labeled Cross-Linker and Mass Spectrometry

Open Access

Peer-reviewed

Research Article

Rama Kannan,

Affiliation Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America
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Puttur Santhoshkumar,

Affiliation Department of Ophthalmology, University of Missouri, Columbia, Missouri, United States of America
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Brian P. Mooney,

Affiliations Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America, University of Missouri, Charles W. Gehrke Proteomics Center, Columbia, Missouri, United States of America
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K. Krishna Sharma

* E-mail: Sharmak@health.missouri.edu

Affiliations Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America, Department of Ophthalmology, University of Missouri, Columbia, Missouri, United States of America
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Protein interactions
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Cross-linking
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Cataracts
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Lysine
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Serine proteases
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Liquid chromatography-mass spectrometry
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