Insulin Promotes Glucose Consumption via Regulation of miR-99a/mTOR/PKM2 Pathway

Wei Li; Jing Wang; Qiu-Dan Chen; Xu Qian; Qi Li; Yu Yin; Zhu-Mei Shi; Lin Wang; Jie Lin; Ling-Zhi Liu; Bing-Hua Jiang

doi:10.1371/journal.pone.0064924

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Open Access

Peer-reviewed

Research Article

Insulin Promotes Glucose Consumption via Regulation of miR-99a/mTOR/PKM2 Pathway

Wei Li ,

Contributed equally to this work with: Wei Li, Jing Wang, Qiu-Dan Chen

Affiliation Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Jing Wang ,

Contributed equally to this work with: Wei Li, Jing Wang, Qiu-Dan Chen

Affiliation Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Qiu-Dan Chen ,

Contributed equally to this work with: Wei Li, Jing Wang, Qiu-Dan Chen

Affiliation Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Xu Qian,

Affiliation Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Qi Li,

Affiliation Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Yu Yin,

Affiliation Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Zhu-Mei Shi,

Affiliation Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⨯
Lin Wang,

Affiliation Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Jie Lin,

Affiliation Faculty of Software, Fujian Normal University, Fuzhou, China
⨯
Ling-Zhi Liu,

Affiliation Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Bing-Hua Jiang

* E-mail: binghjiang@yahoo.com

Affiliations Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China, Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯

Insulin Promotes Glucose Consumption via Regulation of miR-99a/mTOR/PKM2 Pathway

Wei Li,
Jing Wang,
Qiu-Dan Chen,
Xu Qian,
Qi Li,
Yu Yin,
Zhu-Mei Shi,
Lin Wang,
Jie Lin,
Ling-Zhi Liu

Published: June 10, 2013
https://doi.org/10.1371/journal.pone.0064924

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Insulin
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Glucose
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Glucose metabolism
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MicroRNAs
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Transfection
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Immunoblotting
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Hepatocellular carcinoma
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