Protein Arginine Methyltransferase 1 and 8 Interact with FUS to Modify Its Sub-Cellular Distribution and Toxicity In Vitro and In Vivo

Chiara Scaramuzzino; John Monaghan; Carmelo Milioto; Nicholas A. Lanson Jr; Astha Maltare; Tanya Aggarwal; Ian Casci; Frank O. Fackelmayer; Maria Pennuto; Udai Bhan Pandey

doi:10.1371/journal.pone.0061576

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Open Access

Peer-reviewed

Research Article

Protein Arginine Methyltransferase 1 and 8 Interact with FUS to Modify Its Sub-Cellular Distribution and Toxicity In Vitro and In Vivo

Chiara Scaramuzzino ,

Contributed equally to this work with: Chiara Scaramuzzino, John Monaghan

Affiliation Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy
⨯
John Monaghan ,

Contributed equally to this work with: Chiara Scaramuzzino, John Monaghan

Affiliation Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
⨯
Carmelo Milioto,

Affiliation Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy
⨯
Nicholas A. Lanson Jr,

Affiliation Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
⨯
Astha Maltare,

Affiliation Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
⨯
Tanya Aggarwal,

Affiliation Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy
⨯
Ian Casci,

Affiliation Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
⨯
Frank O. Fackelmayer,

Affiliation Laboratory of Epigenetics and Chromosome Biology, Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas (IMBB-FORTH), University Campus, Ioannina, Greece
⨯
Maria Pennuto ,

* E-mail: maria.pennuto@iit.it (MP); upande@lsuhsc.edu (UBP)

Affiliation Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy
⨯
Udai Bhan Pandey

* E-mail: maria.pennuto@iit.it (MP); upande@lsuhsc.edu (UBP)

Affiliation Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
⨯

Protein Arginine Methyltransferase 1 and 8 Interact with FUS to Modify Its Sub-Cellular Distribution and Toxicity In Vitro and In Vivo

Chiara Scaramuzzino,
John Monaghan,
Carmelo Milioto,
Nicholas A. Lanson Jr,
Astha Maltare,
Tanya Aggarwal,
Ian Casci,
Frank O. Fackelmayer,
Maria Pennuto,
Udai Bhan Pandey

Published: April 19, 2013
https://doi.org/10.1371/journal.pone.0061576

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Arginine
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Immunoprecipitation
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Amyotrophic lateral sclerosis
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Methylation
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Pathogenesis
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Motor neurons
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