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Open Access
Peer-reviewed
Research Article
Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization
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J. Saadi Imam,
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Jason R. Plyler ,
Contributed equally to this work with: Jason R. Plyler, Hima Bansal, Suresh Prajapati
Affiliations Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Hima Bansal ,
Contributed equally to this work with: Jason R. Plyler, Hima Bansal, Suresh Prajapati
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Suresh Prajapati ,
Contributed equally to this work with: Jason R. Plyler, Hima Bansal, Suresh Prajapati
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Sanjay Bansal,
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Jennifer Rebeles,
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Hung-I Harry Chen,
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Yao-Fu Chang,
Affiliations Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Subbarayalu Panneerdoss,
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Behyar Zoghi,
Affiliation Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Kalyan C. Buddavarapu,
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Russell Broaddus,
Affiliation Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Peter Hornsby,
Affiliation Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Gail Tomlinson,
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Jeffrey Dome,
Affiliation Center for Cancer and Immunology Research, Children’s National Medical Center, Washington D.C., United States of America
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Ratna K. Vadlamudi,
Affiliation Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Alexander Pertsemlidis,
Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Yidong Chen,
Affiliations Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Manjeet K. Rao
* E-mail: raom@uthscsa.edu
Affiliations Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization
- J. Saadi Imam,
- Jason R. Plyler,
- Hima Bansal,
- Suresh Prajapati,
- Sanjay Bansal,
- Jennifer Rebeles,
- Hung-I Harry Chen,
- Yao-Fu Chang,
- Subbarayalu Panneerdoss,
- Behyar Zoghi
- Published: December 21, 2012
- https://doi.org/10.1371/journal.pone.0052397