RAD001 Enhances the Potency of BEZ235 to Inhibit mTOR Signaling and Tumor Growth

Beat Nyfeler; Yan Chen; Xiaoyan Li; Maria Pinzon-Ortiz; Zuncai Wang; Anupama Reddy; Elina Pradhan; Rita Das; Joseph Lehár; Robert Schlegel; Peter M. Finan; Z. Alexander Cao; Leon O. Murphy; Alan Huang

doi:10.1371/journal.pone.0048548

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Open Access

Peer-reviewed

Research Article

RAD001 Enhances the Potency of BEZ235 to Inhibit mTOR Signaling and Tumor Growth

Beat Nyfeler,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Yan Chen,

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Xiaoyan Li,

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Maria Pinzon-Ortiz,

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Zuncai Wang,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Anupama Reddy,

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Elina Pradhan,

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Rita Das,

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Joseph Lehár,

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Robert Schlegel,

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Peter M. Finan,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Z. Alexander Cao,

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Leon O. Murphy,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯
Alan Huang

* E-mail: alan.huang@novartis.com

Affiliation Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America
⨯

RAD001 Enhances the Potency of BEZ235 to Inhibit mTOR Signaling and Tumor Growth

Beat Nyfeler,
Yan Chen,
Xiaoyan Li,
Maria Pinzon-Ortiz,
Zuncai Wang,
Anupama Reddy,
Elina Pradhan,
Rita Das,
Joseph Lehár,
Robert Schlegel

Published: November 14, 2012
https://doi.org/10.1371/journal.pone.0048548

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