Adoptive Transfer of siRNA Cblb-Silenced CD8+ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model

Reinhard Hinterleitner; Thomas Gruber; Christa Pfeifhofer-Obermair; Christina Lutz-Nicoladoni; Alexander Tzankov; Manfred Schuster; Josef M. Penninger; Hans Loibner; Günther Lametschwandtner; Dominik Wolf; Gottfried Baier

doi:10.1371/journal.pone.0044295

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Peer-reviewed

Research Article

Adoptive Transfer of siRNA Cblb-Silenced CD8⁺ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model

Reinhard Hinterleitner ,

Contributed equally to this work with: Reinhard Hinterleitner, Thomas Gruber, Christa Pfeifhofer-Obermair, Christina Lutz-Nicoladoni, Dominik Wolf, Gottfried Baier

Affiliation Department of Pharmacology and Genetics, Medical University Innsbruck, Innsbruck, Austria
⨯
Thomas Gruber ,

Contributed equally to this work with: Reinhard Hinterleitner, Thomas Gruber, Christa Pfeifhofer-Obermair, Christina Lutz-Nicoladoni, Dominik Wolf, Gottfried Baier

Affiliation Department of Pharmacology and Genetics, Medical University Innsbruck, Innsbruck, Austria
⨯
Christa Pfeifhofer-Obermair ,

Contributed equally to this work with: Reinhard Hinterleitner, Thomas Gruber, Christa Pfeifhofer-Obermair, Christina Lutz-Nicoladoni, Dominik Wolf, Gottfried Baier

Affiliation Department of Pharmacology and Genetics, Medical University Innsbruck, Innsbruck, Austria
⨯
Christina Lutz-Nicoladoni ,

Contributed equally to this work with: Reinhard Hinterleitner, Thomas Gruber, Christa Pfeifhofer-Obermair, Christina Lutz-Nicoladoni, Dominik Wolf, Gottfried Baier

Affiliations Department of Pharmacology and Genetics, Medical University Innsbruck, Innsbruck, Austria, Laboratory of Tumor Immunology, Tyrolean Cancer Research Institute, Innsbruck, Austria
⨯
Alexander Tzankov,

Affiliation Institute of Pathology, University Hospital Basel, Basel, Switzerland
⨯
Manfred Schuster,

Affiliation Apeiron-Biologics AG, Vienna, Austria
⨯
Josef M. Penninger,

Affiliation Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
⨯
Hans Loibner,

Affiliation Apeiron-Biologics AG, Vienna, Austria
⨯
Günther Lametschwandtner,

Affiliation Apeiron-Biologics AG, Vienna, Austria
⨯
Dominik Wolf ,

Contributed equally to this work with: Reinhard Hinterleitner, Thomas Gruber, Christa Pfeifhofer-Obermair, Christina Lutz-Nicoladoni, Dominik Wolf, Gottfried Baier

Affiliations Laboratory of Tumor Immunology, Tyrolean Cancer Research Institute, Innsbruck, Austria, Department of Hematology and Oncology, Medical University Bonn, Bonn, Germany
⨯
Gottfried Baier

Contributed equally to this work with: Reinhard Hinterleitner, Thomas Gruber, Christa Pfeifhofer-Obermair, Christina Lutz-Nicoladoni, Dominik Wolf, Gottfried Baier

* E-mail: Gottfried.Baier@i-med.ac.at

Affiliation Department of Pharmacology and Genetics, Medical University Innsbruck, Innsbruck, Austria
⨯

Adoptive Transfer of siRNA Cblb-Silenced CD8⁺ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model

Reinhard Hinterleitner,
Thomas Gruber,
Christa Pfeifhofer-Obermair,
Christina Lutz-Nicoladoni,
Alexander Tzankov,
Manfred Schuster,
Josef M. Penninger,
Hans Loibner,
Günther Lametschwandtner,
Dominik Wolf

Published: September 4, 2012
https://doi.org/10.1371/journal.pone.0044295

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