Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer

Balaji Krishnamachary; Marie-France Penet; Sridhar Nimmagadda; Yelena Mironchik; Venu Raman; Meiyappan Solaiyappan; Gregg L. Semenza; Martin G. Pomper; Zaver M. Bhujwalla

doi:10.1371/journal.pone.0044078

Loading metrics

Open Access

Peer-reviewed

Research Article

Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer

Balaji Krishnamachary ,

* E-mail: zaver@mri.jhu.edu (ZMB); bkrishn1@jhu.edu (BK)

Affiliation JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Marie-France Penet,

Affiliation JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Sridhar Nimmagadda,

Affiliation JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Yelena Mironchik,

Affiliation JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Venu Raman,

Affiliations JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Meiyappan Solaiyappan,

Affiliation JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Gregg L. Semenza,

Affiliations Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Martin G. Pomper,

Affiliations JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Zaver M. Bhujwalla

* E-mail: zaver@mri.jhu.edu (ZMB); bkrishn1@jhu.edu (BK)

Affiliations JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer

Balaji Krishnamachary,
Marie-France Penet,
Sridhar Nimmagadda,
Yelena Mironchik,
Venu Raman,
Meiyappan Solaiyappan,
Gregg L. Semenza,
Martin G. Pomper,
Zaver M. Bhujwalla

Published: August 28, 2012
https://doi.org/10.1371/journal.pone.0044078

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hypoxia
Is the Subject Area "Hypoxia" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
In vivo imaging
Is the Subject Area "In vivo imaging" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Fluorescence imaging
Is the Subject Area "Fluorescence imaging" applicable to this article?

Thanks for your feedback.
Single photon emission computed tomography
Is the Subject Area "Single photon emission computed tomography" applicable to this article?

Thanks for your feedback.
Metastasis
Is the Subject Area "Metastasis" applicable to this article?

Thanks for your feedback.