An Acenocoumarol Dosing Algorithm Using Clinical and Pharmacogenetic Data in Spanish Patients with Thromboembolic Disease

Alberto M. Borobia; Rubin Lubomirov; Elena Ramírez; Alicia Lorenzo; Armando Campos; Raul Muñoz-Romo; Carmen Fernández-Capitán; Jesús Frías; Antonio J. Carcas

doi:10.1371/journal.pone.0041360

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Peer-reviewed

Research Article

An Acenocoumarol Dosing Algorithm Using Clinical and Pharmacogenetic Data in Spanish Patients with Thromboembolic Disease

Alberto M. Borobia ,

* E-mail: antonio.carcas@uam.es (AJC); a.borobia@gmail.com (AMB)

Affiliation Clinical Pharmacology Service, La Paz University Hospital, Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, IdiPAZ, Madrid, Spain
⨯
Rubin Lubomirov,

Affiliation Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain
⨯
Elena Ramírez,

Affiliation Clinical Pharmacology Service, La Paz University Hospital, Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, IdiPAZ, Madrid, Spain
⨯
Alicia Lorenzo,

Affiliation Internal Medicine Department, La Paz University Hospital, Madrid, Spain
⨯
Armando Campos,

Affiliation Clinical Pharmacology Service, La Paz University Hospital, Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain
⨯
Raul Muñoz-Romo,

Affiliation Clinical Pharmacology Service, La Paz University Hospital, Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain
⨯
Carmen Fernández-Capitán,

Affiliation Internal Medicine Department, La Paz University Hospital, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain
⨯
Jesús Frías,

Affiliation Clinical Pharmacology Service, La Paz University Hospital, Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, IdiPAZ, Madrid, Spain
⨯
Antonio J. Carcas

* E-mail: antonio.carcas@uam.es (AJC); a.borobia@gmail.com (AMB)

Affiliation Clinical Pharmacology Service, La Paz University Hospital, Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, IdiPAZ, Madrid, Spain
⨯

An Acenocoumarol Dosing Algorithm Using Clinical and Pharmacogenetic Data in Spanish Patients with Thromboembolic Disease

Alberto M. Borobia,
Rubin Lubomirov,
Elena Ramírez,
Alicia Lorenzo,
Armando Campos,
Raul Muñoz-Romo,
Carmen Fernández-Capitán,
Jesús Frías,
Antonio J. Carcas

Published: July 20, 2012
https://doi.org/10.1371/journal.pone.0041360

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Dose prediction methods
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Pharmacogenetics
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Coumarins
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Thromboembolism
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Anticoagulant therapy
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Variant genotypes
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