A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

Thomas C. Schulz; Holly Y. Young; Alan D. Agulnick; M. Josephine Babin; Emmanuel E. Baetge; Anne G. Bang; Anindita Bhoumik; Igor Cepa; Rosemary M. Cesario; Carl Haakmeester; Kuniko Kadoya; Jonathan R. Kelly; Justin Kerr; Laura A. Martinson; Amanda B. McLean; Mark A. Moorman; Janice K. Payne; Mike Richardson; Kelly G. Ross; Eric S. Sherrer; Xuehong Song; Alistair Z. Wilson; Eugene P. Brandon; Chad E. Green; Evert J. Kroon; Olivia G. Kelly; Kevin A. D’Amour; Allan J. Robins

doi:10.1371/journal.pone.0037004

Loading metrics

Open Access

Peer-reviewed

Research Article

A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

Thomas C. Schulz ,

* E-mail: tschulz@viacyte.com

Affiliation Viacyte, Inc., Athens, Georgia, United States of America
⨯
Holly Y. Young,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Alan D. Agulnick,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
M. Josephine Babin,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Emmanuel E. Baetge,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Anne G. Bang,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Anindita Bhoumik,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Igor Cepa,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Rosemary M. Cesario,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Carl Haakmeester,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Kuniko Kadoya,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Jonathan R. Kelly,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Justin Kerr,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Laura A. Martinson,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Amanda B. McLean,

Affiliation Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America
⨯
Mark A. Moorman,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Janice K. Payne,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Mike Richardson,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Kelly G. Ross,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Eric S. Sherrer,

Affiliation Viacyte, Inc., Athens, Georgia, United States of America
⨯
Xuehong Song,

Affiliation Viacyte, Inc., Athens, Georgia, United States of America
⨯
Alistair Z. Wilson,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Eugene P. Brandon,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Chad E. Green,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Evert J. Kroon,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Olivia G. Kelly,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
Kevin A. D’Amour,

Affiliation Viacyte, Inc., San Diego, California, United States of America
⨯
[ ... ],
Allan J. Robins

Affiliations Viacyte, Inc., Athens, Georgia, United States of America, Viacyte, Inc., San Diego, California, United States of America
⨯
[ view all ]
[ view less ]

A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

Thomas C. Schulz,
Holly Y. Young,
Alan D. Agulnick,
M. Josephine Babin,
Emmanuel E. Baetge,
Anne G. Bang,
Anindita Bhoumik,
Igor Cepa,
Rosemary M. Cesario,
Carl Haakmeester

Published: May 18, 2012
https://doi.org/10.1371/journal.pone.0037004

Reader Comments (20)

Post a new comment on this article

0 Responses

21 May 2012
22:05 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 22:05 GMT
0 Responses

21 May 2012
22:04 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 22:04 GMT
0 Responses

21 May 2012
22:03 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 22:03 GMT
0 Responses

21 May 2012
22:02 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 22:02 GMT
0 Responses

21 May 2012
22:01 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 22:01 GMT
0 Responses

21 May 2012
21:55 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:55 GMT
0 Responses

21 May 2012
21:54 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:54 GMT
0 Responses

21 May 2012
21:53 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:53 GMT
0 Responses

21 May 2012
21:52 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:52 GMT
0 Responses

21 May 2012
21:52 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:52 GMT
0 Responses

21 May 2012
21:51 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:51 GMT
0 Responses

21 May 2012
21:50 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:50 GMT
0 Responses

21 May 2012
21:50 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:50 GMT
0 Responses

21 May 2012
21:48 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:48 GMT
0 Responses

21 May 2012
21:48 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:48 GMT
0 Responses

21 May 2012
21:47 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:47 GMT
0 Responses

21 May 2012
21:46 GMT
Most Recent

Author Correction Posted by tschulz on 21 May 2012 at 21:46 GMT
0 Responses

21 May 2012
21:46 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:46 GMT
0 Responses

21 May 2012
21:45 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:45 GMT
0 Responses

21 May 2012
21:44 GMT
Most Recent

Author correction Posted by tschulz on 21 May 2012 at 21:44 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Medical implants
Is the Subject Area "Medical implants" applicable to this article?

Thanks for your feedback.
Endoderm
Is the Subject Area "Endoderm" applicable to this article?

Thanks for your feedback.
Immunofluorescence
Is the Subject Area "Immunofluorescence" applicable to this article?

Thanks for your feedback.
Manufacturing processes
Is the Subject Area "Manufacturing processes" applicable to this article?

Thanks for your feedback.
Histology
Is the Subject Area "Histology" applicable to this article?

Thanks for your feedback.
Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Suspension cultures
Is the Subject Area "Suspension cultures" applicable to this article?

Thanks for your feedback.