Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

Open Access

Peer-reviewed

Research Article

Julie Amyot,

Affiliations Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada, Department of Biochemistry, Université de Montréal, Montréal, Quebec, Canada
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Meriem Semache,

Affiliations Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada, Department of Biochemistry, Université de Montréal, Montréal, Quebec, Canada
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Mourad Ferdaoussi,

Affiliation Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada
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Ghislaine Fontés,

Affiliation Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada
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Vincent Poitout

* E-mail: vincent.poitout@umontreal.ca

Affiliations Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada, Department of Biochemistry, Université de Montréal, Montréal, Quebec, Canada, Department of Medicine, Université de Montréal, Montréal, Quebec, Canada
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Insulin
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Transcription factors
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Gene expression
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Glucose
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Insulin secretion
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Immune receptor signaling
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Insulin signaling
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Toll-like receptors
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