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Open Access
Peer-reviewed
Research Article
Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue
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Michael J. Devine ,
Contributed equally to this work with: Michael J. Devine, Alice Kaganovich
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Alice Kaganovich ,
Contributed equally to this work with: Michael J. Devine, Alice Kaganovich
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Mina Ryten,
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Adamantios Mamais,
Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom, Rita Lila Weston Institute and Queen Square Brain Bank, UCL Institute of Neurology, London, United Kingdom
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Daniah Trabzuni,
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Claudia Manzoni,
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Philip McGoldrick,
Affiliation MRC Centre for Neuromuscular Disease, UCL Institute of Neurology, London, United Kingdom
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Diane Chan,
Affiliation Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts, United States of America
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Allissa Dillman,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Julia Zerle,
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Susannah Horan,
Affiliation Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Jan-Willem Taanman,
Affiliation Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom
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John Hardy,
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Jose-Felix Marti-Masso,
Affiliation Hospital Donastia, San Sebastian, Spain
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Daniel Healey,
Current address: Beaumont Hospital, Dublin, Co. Dublin, Ireland,
Affiliation Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Anthony H. Schapira,
Affiliation Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Benjamin Wolozin,
Affiliation Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts, United States of America
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Rina Bandopadhyay,
Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom, Rita Lila Weston Institute and Queen Square Brain Bank, UCL Institute of Neurology, London, United Kingdom
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Mark R. Cookson,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Marcel P. van der Brug ,
* E-mail: mvanderb@scripps.edu (MPvdB); p.lewis@ion.ucl.ac.uk (PAL)
Current address: Genentech Inc., South San Francisco, California, United States of America
Affiliation The Scripps Research Institute, Jupiter, Florida, United States of America
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Patrick A. Lewis
* E-mail: mvanderb@scripps.edu (MPvdB); p.lewis@ion.ucl.ac.uk (PAL)
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue
- Michael J. Devine,
- Alice Kaganovich,
- Mina Ryten,
- Adamantios Mamais,
- Daniah Trabzuni,
- Claudia Manzoni,
- Philip McGoldrick,
- Diane Chan,
- Allissa Dillman,
- Julia Zerle

- Published: July 22, 2011
- https://doi.org/10.1371/journal.pone.0022489