GPVI and GPIbα Mediate Staphylococcal Superantigen-Like Protein 5 (SSL5) Induced Platelet Activation and Direct toward Glycans as Potential Inhibitors

Houyuan Hu; Paul C. J. Armstrong; Elie Khalil; Yung-Chih Chen; Andreas Straub; Min Li; Juliana Soosairajah; Christoph E. Hagemeyer; Nicole Bassler; Dexing Huang; Ingo Ahrens; Guy Krippner; Elizabeth Gardiner; Karlheinz Peter

doi:10.1371/journal.pone.0019190

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Open Access

Peer-reviewed

Research Article

GPVI and GPIbα Mediate Staphylococcal Superantigen-Like Protein 5 (SSL5) Induced Platelet Activation and Direct toward Glycans as Potential Inhibitors

Houyuan Hu ,

Contributed equally to this work with: Houyuan Hu, Paul C. J. Armstrong

Affiliations Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia, Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Paul C. J. Armstrong ,

Contributed equally to this work with: Houyuan Hu, Paul C. J. Armstrong

Affiliation Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
⨯
Elie Khalil,

Affiliation Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
⨯
Yung-Chih Chen,

Affiliations Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia, Department of Medicine, Monash University, Melbourne, Victoria, Australia
⨯
Andreas Straub,

Affiliation Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
⨯
Min Li,

Affiliations Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia, Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Juliana Soosairajah,

Affiliation Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
⨯
Christoph E. Hagemeyer,

Affiliation Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
⨯
Nicole Bassler,

Affiliation Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
⨯
Dexing Huang,

Affiliation Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
⨯
Ingo Ahrens,

Affiliation Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
⨯
Guy Krippner,

Affiliation Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
⨯
Elizabeth Gardiner,

Affiliation Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
⨯
Karlheinz Peter

* E-mail: karlheinz.peter@bakeridi.edu.au

Affiliations Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia, Department of Medicine, Monash University, Melbourne, Victoria, Australia
⨯

GPVI and GPIbα Mediate Staphylococcal Superantigen-Like Protein 5 (SSL5) Induced Platelet Activation and Direct toward Glycans as Potential Inhibitors

Houyuan Hu,
Paul C. J. Armstrong,
Elie Khalil,
Yung-Chih Chen,
Andreas Straub,
Min Li,
Juliana Soosairajah,
Christoph E. Hagemeyer,
Nicole Bassler,
Dexing Huang

Published: April 28, 2011
https://doi.org/10.1371/journal.pone.0019190

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