An Ash2L/RbBP5 Heterodimer Stimulates the MLL1 Methyltransferase Activity through Coordinated Substrate Interactions with the MLL1 SET Domain

• Fang Cao ,

  Contributed equally to this work with: Fang Cao, Yong Chen

  Affiliation Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Yong Chen ,

  Contributed equally to this work with: Fang Cao, Yong Chen

  Affiliation Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America

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• Tomasz Cierpicki,

  Affiliation Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Yifan Liu,

  Affiliation Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Venkatesha Basrur,

  Affiliation Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Ming Lei ,

  * E-mail: yalid@umich.edu (YD); leim@umich.edu (ML)

  Affiliations Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, United States of America

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• Yali Dou

  * E-mail: yalid@umich.edu (YD); leim@umich.edu (ML)

  Affiliations Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America

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