Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

Yi-Chun Loraine Tung; Eduard Ayuso; Xiaoye Shan; Fatima Bosch; Stephen O'Rahilly; Anthony P. Coll; Giles S. H. Yeo

doi:10.1371/journal.pone.0008771

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Peer-reviewed

Research Article

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

Yi-Chun Loraine Tung,

Affiliation University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom
⨯
Eduard Ayuso ,

Contributed equally to this work with: Eduard Ayuso, Xiaoye Shan

Affiliations Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain
⨯
Xiaoye Shan ,

Contributed equally to this work with: Eduard Ayuso, Xiaoye Shan

Affiliation University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom
⨯
Fatima Bosch,

Affiliations Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain
⨯
Stephen O'Rahilly ,

* E-mail: so104@medschl.cam.ac.uk (SO); gshy2@cam.ac.uk (GSHY)

Affiliation University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom
⨯
Anthony P. Coll,

Affiliation University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom
⨯
Giles S. H. Yeo

* E-mail: so104@medschl.cam.ac.uk (SO); gshy2@cam.ac.uk (GSHY)

Affiliation University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom
⨯

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

Yi-Chun Loraine Tung,
Eduard Ayuso,
Xiaoye Shan,
Fatima Bosch,
Stephen O'Rahilly,
Anthony P. Coll,
Giles S. H. Yeo

Published: January 19, 2010
https://doi.org/10.1371/journal.pone.0008771

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