Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells

• Junichi Soh ,

  Contributed equally to this work with: Junichi Soh, Naoki Okumura

  Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

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• Naoki Okumura ,

  Contributed equally to this work with: Junichi Soh, Naoki Okumura

  Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• William W. Lockwood,

  Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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• Hiromasa Yamamoto,

  Affiliation Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

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• Hisayuki Shigematsu,

  Affiliation Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

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• Wei Zhang,

  Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Raj Chari,

  Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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• David S. Shames,

  Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Oncology Diagnostics, Genentech Inc., South San Francisco, California, United States of America

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• Ximing Tang,

  Affiliation Department of Thoracic/Head and Neck, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Calum MacAulay,

  Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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• Marileila Varella-Garcia,

  Affiliation Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, United States of America

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• Tõnu Vooder,

  Affiliation Department of Biotechnology, Institute of Molecular and Cell Biology, Tartu University Hospital, Tartu University, Tartu, Estonia

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• Ignacio I. Wistuba,

  Affiliations Department of Thoracic/Head and Neck, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Stephen Lam,

  Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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• Rolf Brekken,

  Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Shinichi Toyooka,

  Affiliation Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

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• John D. Minna,

  Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Wan L. Lam,

  Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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•  [ ... ],
• Adi F. Gazdar

  * E-mail: Adi.Gazdar@UTSouthwestern.edu

  Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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