Impact of IGFBP-3 A-202C genetic variant on breast cancer susceptibility and serum biomarkers (IGFBP-3 and IGF-1) in Palestinian women

Heba Mohammed Arafat; Tengku Ahmad Damitri Al-Astani; Noorazliyana Shafii; Rosediani Muhamad; Ohood Mohammed Shamallakh; Ihab Naser; Nahed Al Laham; Alaa Siddig

doi:10.1371/journal.pone.0325289

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Open Access

Peer-reviewed

Research Article

Impact of IGFBP-3 A-202C genetic variant on breast cancer susceptibility and serum biomarkers (IGFBP-3 and IGF-1) in Palestinian women

Heba Mohammed Arafat ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hebaarafat4@student.usm.my, damitri@usm.my

Affiliation Department of Chemical Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

https://orcid.org/0000-0003-2710-5673

⨯
Tengku Ahmad Damitri Al-Astani ,

Roles Data curation, Writing – review & editing

* E-mail: hebaarafat4@student.usm.my, damitri@usm.my

Affiliation Department of Chemical Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

https://orcid.org/0000-0003-3265-1679

⨯
Noorazliyana Shafii,

Roles Data curation, Writing – review & editing

Affiliation Department of Chemical Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

https://orcid.org/0000-0002-3959-4534

⨯
Rosediani Muhamad,

Roles Writing – review & editing

Affiliation Department of Family Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

https://orcid.org/0000-0002-8393-7899

⨯
Ohood Mohammed Shamallakh,

Roles Data curation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Medical Laboratory Sciences, Faculty of Health Sciences, Islamic University of Gaza, Gaza City, Palestine
⨯
Ihab Naser,

Roles Data curation, Writing – review & editing

Affiliation Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Al-Azhar University- Gaza, Gaza City, Palestine
⨯
Nahed Al Laham,

Roles Writing – review & editing

Affiliation Department of Laboratory Medicine, Al Azhar University-Gaza, Gaza City, Palestine
⨯
Alaa Siddig

Roles Writing – review & editing

Affiliation Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
⨯

Impact of IGFBP-3 A-202C genetic variant on breast cancer susceptibility and serum biomarkers (IGFBP-3 and IGF-1) in Palestinian women

Heba Mohammed Arafat,
Tengku Ahmad Damitri Al-Astani,
Noorazliyana Shafii,
Rosediani Muhamad,
Ohood Mohammed Shamallakh,
Ihab Naser,
Nahed Al Laham,
Alaa Siddig

Published: June 10, 2025
https://doi.org/10.1371/journal.pone.0325289

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