Recovery after human bone marrow mesenchymal stem cells (hBM-MSCs)-derived extracellular vesicles (EVs) treatment in post-MCAO rats requires repeated handling

Yolanda Gomez-Galvez; Malvika Gupta; Mandeep Kaur; Salvatore Fusco; Maria Vittoria Podda; Claudio Grassi; Amit K. Srivastava; Lorraine Iacovitti; Elena Blanco-Suarez

doi:10.1371/journal.pone.0312298

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Peer-reviewed

Research Article

Recovery after human bone marrow mesenchymal stem cells (hBM-MSCs)-derived extracellular vesicles (EVs) treatment in post-MCAO rats requires repeated handling

Yolanda Gomez-Galvez,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, The Joseph and Marie Field Laboratory for Cerebrovascular Research, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Vickie & Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0001-8729-992X

⨯
Malvika Gupta,

Roles Investigation, Methodology

Affiliation Division of Hematology, Department of Medicine, Cardeza Foundation for Hematologic Research, Sydney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Mandeep Kaur,

Roles Investigation, Methodology

Affiliation Division of Hematology, Department of Medicine, Cardeza Foundation for Hematologic Research, Sydney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Salvatore Fusco,

Roles Investigation, Methodology

Affiliations Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
⨯
Maria Vittoria Podda,

Roles Investigation, Methodology

Affiliations Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
⨯
Claudio Grassi,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
⨯
Amit K. Srivastava,

Roles Resources, Supervision, Writing – review & editing

Affiliation Division of Hematology, Department of Medicine, Cardeza Foundation for Hematologic Research, Sydney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Lorraine Iacovitti ,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: elena.blancosuarez@jefferson.edu (EB-S); lorraine.iacovitti@jefferson.edu (LI)

Affiliations Department of Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, The Joseph and Marie Field Laboratory for Cerebrovascular Research, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Vickie & Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Neurological Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Elena Blanco-Suarez

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: elena.blancosuarez@jefferson.edu (EB-S); lorraine.iacovitti@jefferson.edu (LI)

Affiliations Department of Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, The Joseph and Marie Field Laboratory for Cerebrovascular Research, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Vickie & Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Neurological Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-2131-6376

⨯

Recovery after human bone marrow mesenchymal stem cells (hBM-MSCs)-derived extracellular vesicles (EVs) treatment in post-MCAO rats requires repeated handling

Yolanda Gomez-Galvez,
Malvika Gupta,
Mandeep Kaur,
Salvatore Fusco,
Maria Vittoria Podda,
Claudio Grassi,
Amit K. Srivastava,
Lorraine Iacovitti,
Elena Blanco-Suarez

Published: October 21, 2024
https://doi.org/10.1371/journal.pone.0312298

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