Dose-response relationship of in vivo ambulatory load and mechanosensitive cartilage biomarkers—The role of age, tissue health and inflammation: A study protocol

• Simon Herger ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: simon.herger@unibas.ch

  Affiliations Department of Orthopaedics and Traumatology, University Hospital Basel, Basel, Switzerland, Department of Spine Surgery, University Hospital Basel, Basel, Switzerland, Department of Biomedical Engineering, University of Basel, Basel, Switzerland, Department of Clinical Research, University of Basel, Basel, Switzerland

  https://orcid.org/0000-0001-5207-2100

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• Werner Vach,

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliation Basel Academy for Quality and Research in Medicine, Basel, Switzerland

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• Corina Nüesch,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Orthopaedics and Traumatology, University Hospital Basel, Basel, Switzerland, Department of Spine Surgery, University Hospital Basel, Basel, Switzerland, Department of Biomedical Engineering, University of Basel, Basel, Switzerland, Department of Clinical Research, University of Basel, Basel, Switzerland

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• Anna-Maria Liphardt,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Internal Medicine 3 –Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany, Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany

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• Christian Egloff,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Orthopaedics and Traumatology, University Hospital Basel, Basel, Switzerland, Department of Clinical Research, University of Basel, Basel, Switzerland

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• Annegret Mündermann

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Orthopaedics and Traumatology, University Hospital Basel, Basel, Switzerland, Department of Spine Surgery, University Hospital Basel, Basel, Switzerland, Department of Biomedical Engineering, University of Basel, Basel, Switzerland, Department of Clinical Research, University of Basel, Basel, Switzerland

  https://orcid.org/0000-0002-6472-1689

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