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Open Access
Peer-reviewed
Research Article
Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans
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Danielle van Keulen,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft
Affiliations Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands, Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands, Quorics B.V., Rotterdam, The Netherlands, TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands
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Marianne G. Pouwer,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing
Affiliations TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
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Valur Emilsson,
Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing
Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland
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Ljubica Perisic Matic,
Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing
Affiliation Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden
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Elsbet J. Pieterman,
Roles Methodology, Project administration, Writing – review & editing
Affiliation TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands
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Ulf Hedin,
Roles Conceptualization, Resources, Writing – review & editing
Affiliation Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden
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Vilmundur Gudnason,
Roles Resources, Writing – review & editing
Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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Lori L. Jennings,
Roles Resources, Writing – review & editing
Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States
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Kim Holmstrøm,
Roles Investigation, Methodology, Visualization, Writing – review & editing
Affiliation Bioneer A/S, Hørsholm, Denmark
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Boye Schnack Nielsen,
Roles Investigation, Methodology, Visualization, Writing – review & editing
Affiliation Bioneer A/S, Hørsholm, Denmark
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Gerard Pasterkamp,
Roles Supervision, Writing – review & editing
Affiliation Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
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Jan H. N. Lindeman,
Roles Investigation, Resources, Writing – review & editing
Affiliation Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
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Alain J. van Gool,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
Affiliation TNO- Microbiology & Systems Biology, Zeist, The Netherlands
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Maarten D. Sollewijn Gelpke,
Roles Conceptualization, Supervision, Writing – review & editing
Affiliation Molecular Profiling Consulting, London, United Kingdom
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Hans M. G. Princen ,
Contributed equally to this work with: Hans M. G. Princen, Dennie Tempel
Roles Conceptualization, Resources, Supervision, Writing – review & editing
Affiliation TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands
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Dennie Tempel
Contributed equally to this work with: Hans M. G. Princen, Dennie Tempel
Roles Conceptualization, Supervision, Writing – review & editing
* E-mail: d.tempel@umcutrecht.nl
Affiliations Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands, Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands, Quorics B.V., Rotterdam, The Netherlands, SkylineDx B.V., Rotterdam, The Netherlands
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Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans
- Danielle van Keulen,
- Marianne G. Pouwer,
- Valur Emilsson,
- Ljubica Perisic Matic,
- Elsbet J. Pieterman,
- Ulf Hedin,
- Vilmundur Gudnason,
- Lori L. Jennings,
- Kim Holmstrøm,
- Boye Schnack Nielsen
- Published: August 28, 2019
- https://doi.org/10.1371/journal.pone.0221477