Gain of ALK Gene Copy Number May Predict Lack of Benefit from Anti-EGFR Treatment in Patients with Advanced Colorectal Cancer and RAS-RAF-PI3KCA Wild-Type Status

Filippo Pietrantonio; Claudia Maggi; Maria Di Bartolomeo; Maria Grazia Facciorusso; Federica Perrone; Adele Testi; Roberto Iacovelli; Rosalba Miceli; Ilaria Bossi; Giorgia Leone; Massimo Milione; Giuseppe Pelosi; Filippo de Braud

doi:10.1371/journal.pone.0092147

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Open Access

Peer-reviewed

Research Article

Gain of ALK Gene Copy Number May Predict Lack of Benefit from Anti-EGFR Treatment in Patients with Advanced Colorectal Cancer and RAS-RAF-PI3KCA Wild-Type Status

Filippo Pietrantonio ,

* E-mail: filippo.pietrantonio@istitutotumori.mi.it

Affiliation Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Claudia Maggi,

Affiliation Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Maria Di Bartolomeo,

Affiliation Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Maria Grazia Facciorusso,

Affiliation Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Federica Perrone,

Affiliation Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Adele Testi,

Affiliation Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Roberto Iacovelli,

Affiliation Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Rosalba Miceli,

Affiliation Unit of Medical Statistics Biometry& Bioinformatics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Ilaria Bossi,

Affiliation Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Giorgia Leone,

Affiliation Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Massimo Milione,

Affiliation Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Giuseppe Pelosi,

Affiliation Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Filippo de Braud

Affiliation Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯

Gain of ALK Gene Copy Number May Predict Lack of Benefit from Anti-EGFR Treatment in Patients with Advanced Colorectal Cancer and RAS-RAF-PI3KCA Wild-Type Status

Filippo Pietrantonio,
Claudia Maggi,
Maria Di Bartolomeo,
Maria Grazia Facciorusso,
Federica Perrone,
Adele Testi,
Roberto Iacovelli,
Rosalba Miceli,
Ilaria Bossi,
Giorgia Leone

Published: April 1, 2014
https://doi.org/10.1371/journal.pone.0092147

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