Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

• Kerry Routenberg Love,

  Affiliation Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Timothy J. Politano,

  Affiliation Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Vasiliki Panagiotou,

  Affiliation Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Bo Jiang,

  Affiliation GlycoFi, a wholly-owned subsidiary of Merck and Co., Lebanon, New Hampshire, United States of America

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• Terrance A. Stadheim,

  Affiliation GlycoFi, a wholly-owned subsidiary of Merck and Co., Lebanon, New Hampshire, United States of America

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• J. Christopher Love

  * E-mail: clove@mit.edu

  Affiliation Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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