This question refers to last paragraph of the Discussion section. This is motivated by the large number of women who receive regular treatment with angiotensin converting enzyme inhibitors even after they have been diagnosed with metastatic breast cancer. You propose a model in which direct stimulation of circulating cancer cells by locally produced AngII may influence metastatic colonization.
- According to this model, what could be the effect of this stimulation on metastatic colonisation for women who have had a primitive breast cancer?
- Can you give an estimate of the change in prognosis for 100 women who have had a primitive breast cancer?
- According to this model, what could be the effect of this stimulation on metastatic colonisation for women who already have metastatic breast cancer?