Adaptive Pacing, Cognitive Behaviour Therapy, Graded Exercise, and Specialist Medical Care for Chronic Fatigue Syndrome: A Cost-Effectiveness Analysis

Paul McCrone; Michael Sharpe; Trudie Chalder; Martin Knapp; Anthony L. Johnson; Kimberley A. Goldsmith; Peter D. White

doi:10.1371/journal.pone.0040808

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Research Article

Adaptive Pacing, Cognitive Behaviour Therapy, Graded Exercise, and Specialist Medical Care for Chronic Fatigue Syndrome: A Cost-Effectiveness Analysis

Paul McCrone ,

* E-mail: paul.mccrone@kcl.ac.uk

Affiliation Centre for the Economics of Mental and Physical Health, Health Service and Population Research Department, Institute of Psychiatry, King’s College London, London, United Kingdom
⨯
Michael Sharpe,

Affiliation University Department of Psychiatry, University of Oxford, Oxford, United Kingdom
⨯
Trudie Chalder,

Affiliation Academic Department of Psychological Medicine, King’s College London, London, United Kingdom
⨯
Martin Knapp,

Affiliations Centre for the Economics of Mental and Physical Health, Health Service and Population Research Department, Institute of Psychiatry, King’s College London, London, United Kingdom, Personal Social Services Research Unit, London School of Economics, London, United Kingdom
⨯
Anthony L. Johnson,

Affiliations MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom, MRC Clinical Trials Unit, London, United Kingdom
⨯
Kimberley A. Goldsmith,

Affiliation Biostatistics Department, Institute of Psychiatry, King’s College London, London, United Kingdom
⨯
Peter D. White

Affiliation Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯

Adaptive Pacing, Cognitive Behaviour Therapy, Graded Exercise, and Specialist Medical Care for Chronic Fatigue Syndrome: A Cost-Effectiveness Analysis

Paul McCrone,
Michael Sharpe,
Trudie Chalder,
Martin Knapp,
Anthony L. Johnson,
Kimberley A. Goldsmith,
Peter D. White

Published: August 1, 2012
https://doi.org/10.1371/journal.pone.0040808

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Possible (small) error in data for (post hoc) criteria for improvement

Posted by tkindlon on 03 Aug 2012 at 16:45 GMT

The criteria for improvement in this paper are the same post-hoc dichotomous criteria that were published in the Lancet (the dichotomous criteria for improvement listed in the primary outcome measures in the protocol paper have thus far not been published) (1,2,3). I'm guessing there is an error in either this paper or the Lancet paper as one of the eight sets of figures do not match:
In the current paper, 96 (64.0%) of the participants are said to improve on fatigue with APT; in the Lancet paper, the figure given is 99 (65%).

Incidentally, as I mentioned elsewhere, two letters have been published criticising the post-hoc criteria for improvement (4,5).

References:

1. White PD, Sharpe MC, Chalder T, DeCesare JC, Walwyn R; on behalf of the PACE trial group. Protocol for the PACE trial: a randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise, as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy. BioMed Cent Neurol 2007; 7: 6.
http://www.biomedcentral....

2. White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, et al. (2011) Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet 377:823–836.

3. McCrone P, Sharpe M, Chalder T, Knapp M, Johnson AL, et al. (2012) Adaptive Pacing, Cognitive Behaviour Therapy, Graded Exercise, and Specialist Medical Care for Chronic Fatigue Syndrome: A Cost-Effectiveness Analysis.PLoS ONE 7(8):e40808. doi:10.1371/journal.pone.0040808

4. Stouten B, Goudsmit EM, Riley N. The PACE trial in chronic fatigue syndrome. Lancet. 2011 May 28;377(9780):1832-3; Epub 2011 May 16. http://www.thelancet.com/...(11)60685-5/fulltext

5. Giakoumakis J. The PACE trial in chronic fatigue syndrome. Lancet. 2011 May 28;377(9780):1831. Epub 2011 May 16.
http://www.thelancet.com/...(11)60689-2/fulltext

Competing interests declared: I work in a voluntary (i.e. unpaid) capacity for the Irish ME/CFS Association

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Adaptive Pacing, Cognitive Behaviour Therapy, Graded Exercise, and Specialist Medical Care for Chronic Fatigue Syndrome: A Cost-Effectiveness Analysis

Adaptive Pacing, Cognitive Behaviour Therapy, Graded Exercise, and Specialist Medical Care for Chronic Fatigue Syndrome: A Cost-Effectiveness Analysis

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Possible (small) error in data for (post hoc) criteria for improvement

Posted by tkindlon on 03 Aug 2012 at 16:45 GMT