A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study

Lingjun Zuo; Clarence K. Zhang; Fei Wang; Chiang-Shan R. Li; Hongyu Zhao; Lingeng Lu; Xiang-Yang Zhang; Lin Lu; Heping Zhang; Fengyu Zhang; John H. Krystal; Xingguang Luo

doi:10.1371/journal.pone.0026726

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Peer-reviewed

Research Article

A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study

Lingjun Zuo ,

* E-mail: Lingjun.Zuo@yale.edu (LZ); Xingguang.Luo@yale.edu (XL)

Affiliations Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America
⨯
Clarence K. Zhang,

Affiliation Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Fei Wang,

Affiliations Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang, China
⨯
Chiang-Shan R. Li,

Affiliation Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Hongyu Zhao,

Affiliation Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Lingeng Lu,

Affiliation Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Xiang-Yang Zhang,

Affiliation Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Lin Lu,

Affiliation National Institute on Drug Dependence, Peking University, Beijing, China
⨯
Heping Zhang,

Affiliation Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Fengyu Zhang,

Affiliation Gene, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
John H. Krystal,

Affiliations Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America
⨯
Xingguang Luo

* E-mail: Lingjun.Zuo@yale.edu (LZ); Xingguang.Luo@yale.edu (XL)

Affiliations Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America
⨯

A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study

Lingjun Zuo,
Clarence K. Zhang,
Fei Wang,
Chiang-Shan R. Li,
Hongyu Zhao,
Lingeng Lu,
Xiang-Yang Zhang,
Lin Lu,
Heping Zhang,
Fengyu Zhang

Published: November 7, 2011
https://doi.org/10.1371/journal.pone.0026726

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Novel finding in alcohol dependence

Posted by shrs on 04 Feb 2012 at 05:23 GMT

This in very careful study in whic authors reported the risk gene at PHF3-PTP4A1 locus responsible for alcohol dependence and play a functional role in the this disorder.

No competing interests declared.

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Single nucleotide polymorphisms
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A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study

A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study

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Novel finding in alcohol dependence

Posted by shrs on 04 Feb 2012 at 05:23 GMT