Stalking the Fourth Domain in Metagenomic Data: Searching for, Discovering, and Interpreting Novel, Deep Branches in Marker Gene Phylogenetic Trees

• Dongying Wu,

  Affiliation Department of Evolution and Ecology, Department of Medical Microbiology and Immunology, University of California Davis Genome Center, University of California Davis, Davis, California, United States of America

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• Martin Wu,

  Affiliations Department of Evolution and Ecology, Department of Medical Microbiology and Immunology, University of California Davis Genome Center, University of California Davis, Davis, California, United States of America, University of Virginia, Charlottesville, Virginia, United States of America

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• Aaron Halpern,

  Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

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• Douglas B. Rusch,

  Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

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• Shibu Yooseph,

  Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

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• Marvin Frazier,

  Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

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• J. Craig Venter,

  Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

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• Jonathan A. Eisen

  * E-mail: jaeisen@ucdavis.edu

  Affiliation Department of Evolution and Ecology, Department of Medical Microbiology and Immunology, University of California Davis Genome Center, University of California Davis, Davis, California, United States of America

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