Academic Editor's Review (H. Peter Soyer):

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N.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication, the manuscript has been revised in light of these comments and to address other editorial requirements.
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Review of the original submission:
This is certainly an exciting manuscript on a cutting edge technology. As I am not a technology expert I cannot on the technical aspects.

The concept provided by the authors certainly sounds very promising and opens up new horizons. However, it has been outlined too lengthy in the introduction and in the result and discussion section.

Additional points:

* Usually the patient site in telemedicine is meant to be the remote site. The advanced image reconstruction and hardware control unit is in my understanding the central site. In the first line of page 6 the authors write "remote cutting edge central facility". This is confusing. My proposal would be to simplify the wording. It is obvious that the signing out physician needs not to be physically at this central unit as shown in Fig. 1. It might well be that the authors see the location where the patient and the cellular phone is as the central site and the processing unit is then obviously the remote site. Anyhow, this is only a minor point which can be easily clarified.

* For readers not familiar with the front end technology a better demonstration/explanation of the front end in Fig. 4 and Fig. 5 should be provided.

Review of the first revised manuscript:
The authors certainly present an exciting new concept on medical imaging for patient-centered use in underserved areas.

The manuscript has been shortened considerable and reads now more conciser.

The second part of the first sentence of the results and discussion "by imaging image a simulation of minimally invasive tissue ablation with irreversible electroporation in a medical imaging interventional mode" still is difficult to understand and would need to be rephrased. The reviewer wonders why the authors focus not only on the medical imaging diagnostic mode.