Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment

Rima Kaddurah-Daouk; Rebecca A. Baillie; Hongjie Zhu; Zhao-Bang Zeng; Michelle M. Wiest; Uyen Thao Nguyen; Katie Wojnoonski; Steven M. Watkins; Miles Trupp; Ronald M. Krauss

doi:10.1371/journal.pone.0025482

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Open Access

Peer-reviewed

Research Article

Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment

Rima Kaddurah-Daouk ,

* E-mail: kaddu001@mc.duke.edu (RKD); rkrauss@chori.org (RMK)

Affiliation Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Rebecca A. Baillie,

Affiliation Rosa and Company, Cupertino, California, United States of America
⨯
Hongjie Zhu,

Affiliation Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Zhao-Bang Zeng,

Affiliation Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Michelle M. Wiest,

Affiliation Department of Statistics, University of Idaho, Moscow, Idaho, United States of America
⨯
Uyen Thao Nguyen,

Affiliation Lipomics Technologies-Tethys Bioscience, West Sacramento, California, United States of America
⨯
Katie Wojnoonski,

Affiliation Children's Hospital Oakland Research Institute, Oakland, California, United States of America
⨯
Steven M. Watkins,

Affiliation Lipomics Technologies-Tethys Bioscience, West Sacramento, California, United States of America
⨯
Miles Trupp,

Affiliation Bioinformatics Research Group, AI Center, SRI International, Menlo Park, California, United States of America
⨯
Ronald M. Krauss

* E-mail: kaddu001@mc.duke.edu (RKD); rkrauss@chori.org (RMK)

Affiliation Children's Hospital Oakland Research Institute, Oakland, California, United States of America
⨯

Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment

Rima Kaddurah-Daouk,
Rebecca A. Baillie,
Hongjie Zhu,
Zhao-Bang Zeng,
Michelle M. Wiest,
Uyen Thao Nguyen,
Katie Wojnoonski,
Steven M. Watkins,
Miles Trupp,
Ronald M. Krauss

Published: October 13, 2011
https://doi.org/10.1371/journal.pone.0025482

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 14 Oct 2011 at 18:42 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: TIME
Title: “What Do Gut Bugs Have to Do With Cholesterol? A Lot - - TIME Healthland”
http://healthland.time.co...

Publication: Futurity.org
Title: “Futurity.org - Gut bacteria may affect cholesterol drugs”
http://www.futurity.org/h...

Publication: News One
Title: “Gut bugs could prevent efficacy of cholesterol drugs News”
http://www.inewsone.com/2...

Publication: Newstrack India
Title: “Gut bugs behind why some people don't respond to cholesterol-lowering statin”
http://www.newstrackindia...

Publication: Eureka Alert
Title: “Gut bacteria may affect whether a statin drug lowers cholesterol”
http://www.eurekalert.org...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 21 Oct 2011 at 18:35 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Discover Magazine Blogs
Title: “Foiled From Within: Gut Bacteria Can Decrease Drug Effectiveness | 80beats | Discover Magazine”
http://blogs.discovermaga...

Publication: Bioscholar News
Title: “Gut bugs could prevent efficacy of cholesterol drugs”
http://news.bioscholar.co...

Publication: News Tonight
Title: “Gut Bugs Foil Cholesterol Drug's Efficiency, says Study | News Tonight”
http://newstonight.net/co...

Publication: Private MD Labs
Title: “Gut bacteria may influence effectiveness of cholesterol medications”
http://www.privatemdlabs....

Publication: Med Page Today
Title: “Medical News: Gut Bacteria May Keep Statin Response in Check - in Cardiovascular, Dyslipidemia from MedPage Today”
http://www.medpagetoday.c...

Publication: Third Age
Title: “Gut Flora May Enhance Cholesterol-Lowering Drug Effect | ThirdAge”
http://www.thirdage.com/n...

Publication: Medical News Today
Title: “Gut Bacteria Influence Statin Treatment Response”
http://www.medicalnewstod...

Publication: Emax Health
Title: “Gut flora could explain why cholesterol lowering medicines work sometimes”
http://www.emaxhealth.com...

Publication: Health Jockey
Title: “Gut bacteria supposedly regulate effects of cholesterol-lowering drugs - Health Jockey”
http://www.healthjockey.c...

Publication: Top News Arab Emirates
Title: “Gut Bacteria Weakens Cholesterol Drug Effect: Study | TopNews Arab Emirates”
http://topnews.ae/content...

Publication: Huffington Post
Title: “Effectiveness Of Statins Could Be Determined By Our Gut Bugs, Study Finds”
http://www.huffingtonpost...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

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Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment

Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 14 Oct 2011 at 18:42 GMT

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 21 Oct 2011 at 18:35 GMT