Lipopolysaccharide-Induced Middle Ear Inflammation Disrupts the cochlear Intra-Strial Fluid–Blood Barrier through Down-Regulation of Tight Junction Proteins

Jinhui Zhang; Songlin Chen; Zhiqiang Hou; Jing Cai; Mingmin Dong; Xiaorui Shi

doi:10.1371/journal.pone.0122572

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Open Access

Peer-reviewed

Research Article

Lipopolysaccharide-Induced Middle Ear Inflammation Disrupts the cochlear Intra-Strial Fluid–Blood Barrier through Down-Regulation of Tight Junction Proteins

Jinhui Zhang,

Affiliations Department of Otolaryngology/Head and Neck Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, Oregon Hearing Research Center, Department of Otolaryngology/Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Songlin Chen,

Affiliation Oregon Hearing Research Center, Department of Otolaryngology/Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Zhiqiang Hou,

Affiliation Oregon Hearing Research Center, Department of Otolaryngology/Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Jing Cai,

Affiliation Oregon Hearing Research Center, Department of Otolaryngology/Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Mingmin Dong,

Affiliation Department of Otolaryngology/Head and Neck Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
⨯
Xiaorui Shi

* E-mail: shix@ohsu.edu

Affiliation Oregon Hearing Research Center, Department of Otolaryngology/Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, United States of America
⨯

Lipopolysaccharide-Induced Middle Ear Inflammation Disrupts the cochlear Intra-Strial Fluid–Blood Barrier through Down-Regulation of Tight Junction Proteins

Jinhui Zhang,
Songlin Chen,
Zhiqiang Hou,
Jing Cai,
Mingmin Dong,
Xiaorui Shi

Published: March 27, 2015
https://doi.org/10.1371/journal.pone.0122572

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Dual Corresponding Author Update

Posted by xiaoruishi on 21 Apr 2015 at 19:05 GMT

This paper has two corresponding authors: Xiaorui Shi, MD, PhD, Oregon Health & Science University, USA and Mingmin Dong, MD, PhD, Department of Otolaryngology/Head and Neck Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

No competing interests declared.

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Vascular permeability
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Middle ear
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Cytokines
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Inflammation
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Protein expression
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Mouse models
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Cochlea
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Otitis media
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Lipopolysaccharide-Induced Middle Ear Inflammation Disrupts the cochlear Intra-Strial Fluid–Blood Barrier through Down-Regulation of Tight Junction Proteins

Lipopolysaccharide-Induced Middle Ear Inflammation Disrupts the cochlear Intra-Strial Fluid–Blood Barrier through Down-Regulation of Tight Junction Proteins

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Dual Corresponding Author Update

Posted by xiaoruishi on 21 Apr 2015 at 19:05 GMT