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BMP15 fitness overdominance

Posted by harpend on 28 Dec 2006 at 16:39 GMT

Surprisingly, BMP15 and GDF9 have never been explicitly referred to as characteristic of heterozygote advantage and genotype fitnesses have never been estimated at these genes.

We assumed that fitness overdominance for this locus was clearcut and used it as an example in:

J Biosoc Sci. 2006 Sep;38(5):659-93.
Natural history of Ashkenazi intelligence.
Cochran G, Hardy J, Harpending H.