Reader Comments

Post a new comment on this article

BMP15 fitness overdominance

Posted by harpend on 28 Dec 2006 at 16:39 GMT

Surprisingly, BMP15 and GDF9 have never been explicitly referred to as characteristic of heterozygote advantage and genotype fitnesses have never been estimated at these genes.
http://plosone.org/article/info:doi/10.1371/journal.pone.0000125#article1.body1.sec1.p2

We assumed that fitness overdominance for this locus was clearcut and used it as an example in:

J Biosoc Sci. 2006 Sep;38(5):659-93.
Natural history of Ashkenazi intelligence.
Cochran G, Hardy J, Harpending H.