TY - JOUR T1 - Conventional vs. Tablet Computer-Based Patient Education following Lung Transplantation – A Randomized Controlled Trial A1 - Suhling, Hendrik A1 - Rademacher, Jessica A1 - Zinowsky, Imke A1 - Fuge, Jan A1 - Greer, Mark A1 - Warnecke, Gregor A1 - Smits, Jacqueline M. A1 - Bertram, Anna A1 - Haverich, Axel A1 - Welte, Tobias A1 - Gottlieb, Jens Y1 - 2014/03/07 N2 - Background Accurate immunosuppression is of critical importance in preventing rejection, while avoiding toxicity following lung transplantation. The mainstay immunosuppressants are calcineurin inhibitors, which require regular monitoring due to interactions with other medications and diet. Adherence to immunosuppression and patient knowledge is vital and can be improved through patient education. Education using tablet-computers was investigated. Objective To compare tablet-PC education and conventional education in improving immunosuppression trough levels in target range 6 months after a single education. Secondary parameters were ratio of immunosuppression level measurements divided by per protocol recommended measurements, time and patient satisfaction regarding education. Design Single-centre, open labelled randomised controlled trial. Participants Patients >6 months after lung-transplantation with <50% of calcineurin inhibitor trough levels in target range. Intervention Tablet-pc education versus personal, nurse-led education. Measurements Calcineurin inhibitor levels in target range 6 months after education, level variability, interval adherence, knowledge and adherence was studied. As outcome parameter, renal function was measured and adverse events registered. Results Sixty-four patients were 1:1 randomised for either intervention. Levels of immunosuppression 6 months after education were equal (tablet-PC 58% vs. conventional 48%, p = 0.27), both groups improved in achieving a CNI trough level within target range by either education method (delta tablet-PC 29% vs. conventional 20%). In all patients, level variability decreased (−20.4%), whereas interval adherence remained unchanged. Knowledge about immunosuppression improved by 7% and compliance tests demonstrated universal improvements with no significant difference between groups. Conclusion Education is a simple, effective tool in improving adherence to immunosuppression. Tablet-PC education was non-inferior to conventional education. Trial Registration ClinicalTrials.gov NCT01398488 http://clinicaltrials.gov/ct2/show/NCT01398488?term=gottlieb+tablet+pc+education&rank=1. JF - PLOS ONE JA - PLOS ONE VL - 9 IS - 3 UR - https://doi.org/10.1371/journal.pone.0090828 SP - e90828 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pone.0090828 ER -