About the Authors

Kazuhiko Uchida

Contributed equally to this work with: Kazuhiko Uchida, Kohji Meno

Roles Conceptualization, Writing – original draft, Writing – review & editing

kazuhiko.uchida@cbiri.org

Affiliations Institute of Biomedical Research, MCBI Inc., Tsukuba, Ibaraki, Japan, Research Division, MCBI Inc., Tsukuba, Ibaraki, Japan

Kohji Meno

Contributed equally to this work with: Kazuhiko Uchida, Kohji Meno

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliation Research Division, MCBI Inc., Tsukuba, Ibaraki, Japan

Tatsumi Korenaga

Roles Formal analysis, Investigation, Resources

Affiliation Research Division, MCBI Inc., Tsukuba, Ibaraki, Japan

Shan Liu

Roles Data curation, Formal analysis, Investigation

Affiliation Research Division, MCBI Inc., Tsukuba, Ibaraki, Japan

Hideaki Suzuki

Roles Data curation, Formal analysis, Resources

Affiliation Research Division, MCBI Inc., Tsukuba, Ibaraki, Japan

Yoshitake Baba

Roles Investigation

Affiliation Central Research Institute, ITO EN, LTD., Makinohara, Shizuoka, Japan

Chika Tagata

Roles Investigation

Affiliation Central Research Institute, ITO EN, LTD., Makinohara, Shizuoka, Japan

Yoshiharu Araki

Roles Investigation

Affiliation Central Research Institute, ITO EN, LTD., Makinohara, Shizuoka, Japan

Shuto Tsunemi

Roles Investigation

Affiliation Central Research Institute, ITO EN, LTD., Makinohara, Shizuoka, Japan

Kenta Aso

Roles Investigation

Affiliation Central Research Institute, ITO EN, LTD., Makinohara, Shizuoka, Japan

Shun Inagaki

Roles Investigation

Affiliation Central Research Institute, ITO EN, LTD., Makinohara, Shizuoka, Japan

Sae Nakagawa

Roles Investigation, Resources

Affiliation Central Research Institute, ITO EN, LTD., Makinohara, Shizuoka, Japan

Makoto Kobayashi

Roles Investigation, Resources

Affiliation Central Research Institute, ITO EN, LTD., Makinohara, Shizuoka, Japan

Tatsuyuki Kakuma

Roles Data curation, Supervision, Validation

Affiliation Biostatistics Center, Kurume University Graduate School of Medicine, Kurume, Japan

Takashi Asada

Roles Resources, Supervision

Affiliations Memory Clinic Toride, Toride, Ibaraki, Japan, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

Miho Ota

Roles Investigation, Resources

Affiliation Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

Takanobu Takihara

Roles Supervision, Validation, Writing – review & editing

Affiliation Central Research Institute, ITO EN, LTD., Makinohara, Shizuoka, Japan

Tetsuaki Arai

Roles Resources, Supervision, Validation

Affiliation Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

Competing Interests

Authors with competing interests Enter competing interest details beginning with this statement: I have read the journal’s policy and the authors of this manuscript have the following competing interests: [Kazuhiko Uchida serves as a board member of MCBI Inc. Kohji Meno, Tatsumi Korenaga, Liu Shan, and Hideaki Suzuki are employees of MCBI Inc. Yoshitake Baba, Chika Tagata, Yoshiharu Araki, Shuto Tsunemi, Kenta Aso, Shun Inagaki, Sae Nakagawa, Makoto Kobayashi, and Takanobu Takihara are employees of ITO EN, LTD. This research received no external funding.] This does not alter our adherence to PLOS ONE policies on sharing data and materials.