About the Authors

Joanna McLaughlin

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Writing – original draft, Writing – review & editing

joanna.mclaughlin@bristol.ac.uk

Affiliation Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building, Level 1, Southmead Hospital, Bristol, United Kingdom

Ruth Kipping

Roles Supervision, Writing – review & editing

Affiliation Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Amanda Owen-Smith

Roles Supervision, Writing – review & editing

Affiliation Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Hugh McLeod

Roles Supervision, Writing – review & editing

Affiliations Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, National Institute for Health Research Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom

Samuel Hawley

Roles Methodology, Writing – review & editing

Affiliation Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building, Level 1, Southmead Hospital, Bristol, United Kingdom

J Mark Wilkinson

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Department of Oncology and Metabolism, The Mellanby Centre for Musculoskeletal Research, University of Sheffield, Metabolic Bone Unit, Sorby Wing, Northern General Hospital, Sheffield, United Kingdom

Andrew Judge

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliations Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building, Level 1, Southmead Hospital, Bristol, United Kingdom, National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, Kingdom

Competing Interests

All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf and declare: AJ has received consultancy fees from Freshfields Bruckhaus Deringer and has held advisory board positions (which involved receipt of fees) from Anthera Pharmaceuticals, INC, outside the submitted work; no other relationships or activities that could appear to have influenced the submitted work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.