About the Authors

Jean-Pierre Boissel

Contributed equally to this work with: Jean-Pierre Boissel, David Pérol, Hervé Décousus, Ingrid Klingmann, Marc Hommel

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

jean-pierre.boissel@novadiscovery.com

Affiliation Novadiscovery, Lyon, France

David Pérol

Contributed equally to this work with: Jean-Pierre Boissel, David Pérol, Hervé Décousus, Ingrid Klingmann, Marc Hommel

Roles Validation, Visualization, Writing – review & editing

Affiliation Department of Biostatistics, Centre Léon Bérard, Lyon, France

Hervé Décousus

Contributed equally to this work with: Jean-Pierre Boissel, David Pérol, Hervé Décousus, Ingrid Klingmann, Marc Hommel

Roles Validation, Visualization, Writing – review & editing

Affiliation INSERM, CIC 1408—F Crin, INNOVTE, CHU Saint-Etienne, Hôpital Nord, Service Médecine Vasculaire et Thérapeutique, Saint Etienne, France

Ingrid Klingmann

Contributed equally to this work with: Jean-Pierre Boissel, David Pérol, Hervé Décousus, Ingrid Klingmann, Marc Hommel

Roles Project administration, Validation, Visualization, Writing – review & editing

Affiliation European Forum for Good Clinical Practice (EFGCP), Brussels, Belgium

Marc Hommel

Contributed equally to this work with: Jean-Pierre Boissel, David Pérol, Hervé Décousus, Ingrid Klingmann, Marc Hommel

Roles Funding acquisition, Project administration, Validation, Visualization, Writing – review & editing

Affiliations Novadiscovery, Lyon, France, University Hospital Grenoble, Grenoble, EA 4407 AGEIS UGA, France

Competing Interests

All authors have completed the Unified Competing Interest form (available on request from the corresponding author) and declare: no support from any organization for the submitted work [or describe if any]; no financial relationships with any organizations that might have an interest in the submitted work in the previous three years [or describe if any], no other relationships or activities that could appear to have influenced the submitted work [or describe if any].This does not alter our adherence to PLOS ONE policies on sharing data and materials.