About the Authors

David W. Kang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Writing – original draft, Writing – review & editing

dkang@halozyme.com

Affiliation Halozyme Therapeutics, Inc., San Diego, CA, United States of America

Beate Bittner

Roles Writing – original draft, Writing – review & editing

Affiliation F. Hoffmann-La Roche Ltd., Basel, Switzerland

Barry J. Sugarman

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

Affiliation Formerly with Halozyme Therapeutics, Inc., San Diego, CA, United States of America

Monica L. Zepeda

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

Affiliation Formerly with Halozyme Therapeutics, Inc., San Diego, CA, United States of America

Marie A. Printz

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Halozyme Therapeutics, Inc., San Diego, CA, United States of America

Competing Interests

Study was funded by Halozyme Therapeutics, Inc. D.W.K, M.A.P and M.L.Z. hold shares in Halozyme Therapeutics, Inc. D.W.K. and M.A.P. are employees of Halozyme Therapeutics, Inc. B.J.S. and M.L.Z. are former employees of Halozyme Therapeutics, Inc. but were employees at the time of the study. All employees/former employees were salaried by Halozyme Therapeutics, Inc. B.B. is an employee of and holds shares in F. Hoffmann-La Roche Ltd. The sponsor was involved in the study design, collection, analysis, and interpretation of data, as well as data checking of information provided in the manuscript. However, ultimate responsibility for opinions, conclusions, and data interpretation lies with the authors. This does not alter our adherence to PLOS ONE policies on sharing data and materials.